ACRNaCT trial protocol: efficacy of adjuvant chemotherapy in patients with clinical T3b/T4, N+ rectal Cancer undergoing Neoadjuvant Chemoradiotherapy: a pathology-oriented, prospective, multicenter, randomized, open-label, parallel group clinical trial

[1] Bray F(2018)Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin 68 394-424

[2] Ferlay J(2010)Revised tumor and node categorization for rectal cancer based on surveillance, epidemiology, and end results and rectal pooled analysis outcomes J Clin Oncol 28 256-263

[3] Soerjomataram I(2004)Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 1731-1740

[4] Siegel RL(2012)Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years J Clin Oncol 30 1926-1933

[5] Torre LA(2012)Postoperative adjuvant chemotherapy in rectal cancer operated for cure Cochrane Database Syst Rev 3 184-190

[6] Jemal A(2014)Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study Lancet Oncol 15 223-229

[7] Gunderson LL(2014)No benefit of adjuvant fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): long term results of a randomized trial (I-CNR-RT) Radiother Oncol 113 696-701

[8] Jessup JM(2015)Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo) radiotherapy and total mesorectal excision: a Dutch colorectal Cancer group (DCCG) randomized phase III trial Ann Oncol 26 1356-1362

[9] Sargent DJ(2014)Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control Ann Oncol 25 200-207

[10] Greene FL(2015)Adjuvant chemotherapy after preoperative (chemo) radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data Lancet Oncol 16 1245-1253

[1] Bray F(2018)Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries CA Cancer J Clin 68 394-424

[2] Ferlay J(2010)Revised tumor and node categorization for rectal cancer based on surveillance, epidemiology, and end results and rectal pooled analysis outcomes J Clin Oncol 28 256-263

[3] Soerjomataram I(2004)Preoperative versus postoperative chemoradiotherapy for rectal cancer N Engl J Med 351 1731-1740

[4] Siegel RL(2012)Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer: results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years J Clin Oncol 30 1926-1933

[5] Torre LA(2012)Postoperative adjuvant chemotherapy in rectal cancer operated for cure Cochrane Database Syst Rev 3 184-190

[6] Jemal A(2014)Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study Lancet Oncol 15 223-229

[7] Gunderson LL(2014)No benefit of adjuvant fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): long term results of a randomized trial (I-CNR-RT) Radiother Oncol 113 696-701

[8] Jessup JM(2015)Adjuvant chemotherapy for rectal cancer patients treated with preoperative (chemo) radiotherapy and total mesorectal excision: a Dutch colorectal Cancer group (DCCG) randomized phase III trial Ann Oncol 26 1356-1362

[9] Sargent DJ(2014)Chronicle: results of a randomised phase III trial in locally advanced rectal cancer after neoadjuvant chemoradiation randomising postoperative adjuvant capecitabine plus oxaliplatin (XELOX) versus control Ann Oncol 25 200-207

[10] Greene FL(2015)Adjuvant chemotherapy after preoperative (chemo) radiotherapy and surgery for patients with rectal cancer: a systematic review and meta-analysis of individual patient data Lancet Oncol 16 1245-1253