A genome screen for multiple sclerosis in Italian families

被引：0
作者：
S Broadley
S Sawcer
S D’Alfonso
A Hensiek
F Coraddu
J Gray
R Roxburgh
D Clayton
C Buttinelli
A Quattrone
M Trojano
L Massacesi
A Compston
机构：
[1] University of Cambridge Neurology Unit,Department of Medical Sciences
[2] Addenbrooke’s Hospital,Department of Neurological Sciences
[3] Chair of Human Genetics,Department of Medical Sciences
[4] University of Piemonte Orientale ‘A. Avogadro’,Department of Neurological and Psychiatric Sciences
[5] MRC Biostatistics Unit,Department of Neurological and Psychiatric Sciences
[6] Institute of Public Health,undefined
[7] University Forvie Site,undefined
[8] University “La Sapienza”,undefined
[9] University of Catanzaro and Institute of Experimental Medicine and Biotechnology,undefined
[10] University of Bari,undefined
[11] University of Florence,undefined
来源：
Genes & Immunity | 2001年 / 2卷
关键词：
multiple sclerosis; linkage; genome screen; genetic susceptibility;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.
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页码：205 / 210
页数：5
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