Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review

被引：0
作者：
Fatemeh Yarmohammadi
A. Wallace Hayes
Gholamreza Karimi
机构：
[1] Mashhad University of Medical Sciences,Student Research Committee
[2] Mashhad University of Medical Sciences,Department of Pharmacodynamics and Toxicology, School of Pharmacy
[3] University of South Florida,Center for Environmental Occupational Risk Analysis and Management, College of Public Health
[4] Mashhad University of Medical Sciences,Pharmaceutical Research Center, Pharmaceutical Technology Institute
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2021年 / 394卷
关键词：
Mitochondrial dysfunction; Herat injury; Oxidative stress; Inflammation; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cardiotoxicity is a major adverse effect that can be induced by both therapeutic agents and industrial chemicals. The pathogenesis of such cardiac damage is multifactorial, often injuring the cardiac tissue by generating free radicals, oxidative stress, and/or inflammation. Curcumin (CUR) is a bright yellow chemical produced by Curcuma longa plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. Administration of CUR has been reported to ameliorate the chemical and drug-induced cardiac injury in several studies. CUR has been suggested to act as an effective candidate against oxidative stress and inflammation in heart tissue via regulation of Nrf2 and suppression of p38 MAPK/NF-κB and NLRP3 inflammasomes. The anti-apoptotic properties of CUR have also been reported to modulate the AMPK, Akt, JNK, and ERK signaling pathways. This review explores the potential protective effects of CUR regarding the detrimental effects often observed in cardiac tissue following exposure to several chemicals including drugs.
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页码：1341 / 1353
页数：12
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  • [91] Hornung V(2009)Cisplatin ototoxicity and protection: clinical and experimental studies Tohoku J Exp Med 219 709-182
  • [92] Benzer F(2013)Oxidative damage to macromolecules in human Parkinson disease and the rotenone model Free Radic Biol Med 62 1-53
  • [93] Kandemir FM(2018)Curcumin-mediated anti-microbial photodynamic therapy against Candida dubliniensis biofilms Lasers Med Sci 33 112-77
  • [94] Ozkaraca M(2014)Titanium dioxide nanoparticles promote arrhythmias via a direct interaction with rat cardiac tissue Particle and Fibre Toxicology 11 104335-489
  • [95] Kucukler S(2020)Toxicity of pioglitazone on mitochondria isolated from brain and heart: an analysis for probable drug-induced neurotoxicity and cardiotoxicity Drug Research 70 4-2273
  • [96] Caglayan C(2019)Curcumin and its analogues protect from endoplasmic reticulum stress: mechanisms and pathways Pharmacol Res 146 231-227
  • [97] Bhatt L(2019)Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation Biotechnol Appl Biochem 66 291-76
  • [98] Sebastian B(2011)ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells Toxicol in Vitro 25 211-329
  • [99] Joshi V(1997)Oxidative stress: oxidants and antioxidants Experimental Physiology: Translation and Integration 82 365-H1467
  • [100] Bhutiani N(2018)Toxicity, degradation and analysis of the herbicide atrazine Environ Chem Lett 16 978-427
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