Protective effects of curcumin on chemical and drug-induced cardiotoxicity: a review

被引：0
作者：
Fatemeh Yarmohammadi
A. Wallace Hayes
Gholamreza Karimi
机构：
[1] Mashhad University of Medical Sciences,Student Research Committee
[2] Mashhad University of Medical Sciences,Department of Pharmacodynamics and Toxicology, School of Pharmacy
[3] University of South Florida,Center for Environmental Occupational Risk Analysis and Management, College of Public Health
[4] Mashhad University of Medical Sciences,Pharmaceutical Research Center, Pharmaceutical Technology Institute
来源：
Naunyn-Schmiedeberg's Archives of Pharmacology | 2021年 / 394卷
关键词：
Mitochondrial dysfunction; Herat injury; Oxidative stress; Inflammation; Apoptosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cardiotoxicity is a major adverse effect that can be induced by both therapeutic agents and industrial chemicals. The pathogenesis of such cardiac damage is multifactorial, often injuring the cardiac tissue by generating free radicals, oxidative stress, and/or inflammation. Curcumin (CUR) is a bright yellow chemical produced by Curcuma longa plants. It is the principal curcuminoid of turmeric (Curcuma longa), a member of the ginger family, Zingiberaceae. Administration of CUR has been reported to ameliorate the chemical and drug-induced cardiac injury in several studies. CUR has been suggested to act as an effective candidate against oxidative stress and inflammation in heart tissue via regulation of Nrf2 and suppression of p38 MAPK/NF-κB and NLRP3 inflammasomes. The anti-apoptotic properties of CUR have also been reported to modulate the AMPK, Akt, JNK, and ERK signaling pathways. This review explores the potential protective effects of CUR regarding the detrimental effects often observed in cardiac tissue following exposure to several chemicals including drugs.
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页码：1341 / 1353
页数：12
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