Protocol of a randomised delayed-start double-blind placebo-controlled multi-centre trial for Levodopa in EArly Parkinson’s disease: the LEAP-study

被引：0
|
作者：
Constant V. M. Verschuur
S. R. Suwijn
B. Post
M. Dijkgraaf
B. R. Bloem
J. J. van Hilten
T. van Laar
G. Tissingh
G. Deuschl
A. E. Lang
R. J. de Haan
R. M. A. de Bie
机构：
[1] University of Amsterdam,Department of Neurology, Academic Medical Center
[2] Radboud University Medical Center,Department of Neurology, Donders Institute for Brain, Cognition and Behavior
[3] Clinical Research Unit,Academic Medical Center
[4] Leiden University Medical Center,Department of Neurology
[5] University Medical Center Groningen,Department of Neurology
[6] Atrium-Orbis Medical Center Heerlen/Sittard,Department of Neurology
[7] University Medical Center Schleswig-Holstein,Department of Neurology
[8] University of Toronto,The Edmond J. Safra Program in Parkinson’s Disease and Morton and Gloria Shulman Movement Disorders Center, Toronto Western Hospital
来源：
BMC Neurology | / 15卷
关键词：
Parkinson’s disease; Levodopa; Randomised delayed-start placebo-controlled trial; Disease modifying;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] A Randomized, Double-Blind, Placebo-Controlled, Delayed Start Study to Assess Rasagiline as a Disease Modifying Therapy in Parkinson's Disease (The ADAGIO Study): Rationale, Design, and Baseline Characteristics
    Olanow, C. Warren
    Hauser, Robert A.
    Jankovic, Joseph
    Langston, William
    Lang, Anthony
    Poewe, Werner
    Tolosa, Eduardo
    Stocchi, Fabrizio
    Melamed, Eldad
    Eyal, Eli
    Rascol, Olivier
    MOVEMENT DISORDERS, 2008, 23 (15) : 2194 - 2201
  • [32] Pilot study of H2 therapy in Parkinson's disease: A randomized double-blind placebo-controlled trial
    Yoritaka, Asako
    Takanashi, Masashi
    Hirayama, Masaaki
    Nakahara, Toshiki
    Ohta, Shigeo
    Hattori, Nobutaka
    MOVEMENT DISORDERS, 2013, 28 (06) : 836 - 839
  • [33] Apomorphine sublingual film for off episodes in Parkinson's disease: a randomised, double-blind, placebo-controlled phase 3 study
    Olanow, C. Warren
    Factor, Stewart A.
    Espay, Alberto J.
    Hauser, Robert A.
    Shill, Holly A.
    Isaacson, Stuart
    Pahwa, Rajesh
    Leinonen, Mika
    Bhargava, Parul
    Sciarappa, Ken
    Navia, Bradford
    Blum, David
    LANCET NEUROLOGY, 2020, 19 (02) : 135 - 144
  • [34] Opicapone as an Add-on to Levodopa in Patients with Parkinson's Disease Without Motor Fluctuations: Rationale and Design of the Phase III, Double-Blind, Randomised, Placebo-Controlled EPSILON Trial
    Ferreira, Joaquim J.
    Poewe, Werner
    Rascol, Olivier
    Stocchi, Fabrizio
    Antonini, Angelo
    Moreira, Joana
    Pereira, Ana
    Rocha, Jose-Francisco
    Soares-da-Silva, Patricio
    NEUROLOGY AND THERAPY, 2022, 11 (03) : 1409 - 1425
  • [35] Opicapone as an Add-on to Levodopa in Patients with Parkinson’s Disease Without Motor Fluctuations: Rationale and Design of the Phase III, Double-Blind, Randomised, Placebo-Controlled EPSILON Trial
    Joaquim J. Ferreira
    Werner Poewe
    Olivier Rascol
    Fabrizio Stocchi
    Angelo Antonini
    Joana Moreira
    Ana Pereira
    José-Francisco Rocha
    Patrício Soares-da-Silva
    Neurology and Therapy, 2022, 11 : 1409 - 1425
  • [36] Pardoprunox as adjunct therapy to levodopa in patients with Parkinson's disease experiencing motor fluctuations: Results of a double-blind, randomized, placebo-controlled, trial
    Rascol, O.
    Bronzova, J.
    Hauser, R. A.
    Lang, A. E.
    Sampaio, C.
    Theeuwes, A.
    Van de Witte, S. V.
    PARKINSONISM & RELATED DISORDERS, 2012, 18 (04) : 370 - 376
  • [37] Efficacy of Yokukansankachimpihange on sleep disturbance in Parkinson's disease A study protocol of a randomized, double blind, placebo-controlled pilot trial
    Jang, Jung-Hee
    Lee, JuAh
    Jung, Inchul
    Yoo, Horyong
    MEDICINE, 2018, 97 (26)
  • [38] Botulinum toxin type A for drooling in Parkinson's disease: A double-blind, randomized, placebo-controlled study
    Lagalla, Giovanni
    Millevolte, Marzia
    Capecci, Marianna
    Provinciali, Leandro
    Ceravolo, Maria Gabriella
    MOVEMENT DISORDERS, 2006, 21 (05) : 704 - 707
  • [39] Apomorphine subcutaneous infusion in patients with Parkinson's disease with persistent motor fluctuations (TOLEDO): a multicentre, double-blind, randomised, placebo-controlled trial
    Katzenschlager, Regina
    Poewe, Werner
    Rascol, Olivier
    Trenkwalder, Claudia
    Deuschl, Gunther
    Chaudhuri, K. Ray
    Henriksen, Tove
    van Laar, Teus
    Spivey, Kevin
    Vel, Senthil
    Staines, Harry
    Lees, Andrew
    LANCET NEUROLOGY, 2018, 17 (09) : 749 - 759
  • [40] Early Treatment of Parkinson’s Disease with Cabergoline Delays the Onset of Motor ComplicationsResults of a Double-Blind Levodopa Controlled Trial
    U. K. Rinne
    F. Bracco
    C. Chouza
    E. Dupont
    O. Gershanik
    J. F. Marti Masso
    J. L. Montastruc
    C. D. Marsden
    Drugs, 1998, 55 : 23 - 30
12345