1H, 13C, 15N backbone and side-chain chemical shift assignments of the polyketide cyclase from Mycobacterium tuberculosis

被引：0
作者：
Shihui Fan
Jie Zhuang
Chenyun Guo
Donghai Lin
Xinli Liao
机构：
[1] Xiamen University,Department of Chemical Biology, College of Chemistry and Chemical Engineering
来源：
Biomolecular NMR Assignments | 2021年 / 15卷
关键词：
Tuberculosis; Polyketide cyclase; NMR; Chemical shift assignment;
D O I：
暂无
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学科分类号：
摘要：
Polyketide cyclase from Mycobacterium tuberculosis (MtPC) is related to the formation of sterol derivatives, which may play a role in immune escape in the initial stage of macrophage infection by Mycobacterium tuberculosis. However, the structure and specific functions of MtPC are still unknown. Here we report the backbone and side-chain NMR resonance assignments for the MtPC. Most resonances were assigned and the secondary structure was predicted according to the assigned backbone resonances by TALOS-N and PECAN. These NMR assignments represent a first step towards researching the structure and function of MtPC.
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页码：397 / 402
页数：5
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