Pathogenesis of chronic pancreatitis

被引：1

作者：

Rosendahl, Jonas ^{[1
]}

Witt, Heiko ^{[2
]}

机构：

[1] Martin Luther Univ Halle Wittenberg, Univ Klinikum Halle Saale, Klin Innere Med 1, Ernst Grube Str 40, D-06120 Halle, Saale, Germany

[2] Tech Univ Munchen TUM, Padiat Ernahrungsmed, Else Kroner Fresenius Zentrum Ernahrungsmed EKFZ, Gregor Mendel Str 2, D-85354 Freising Weihenstephan, Germany

来源：

INTERNIST | 2021年 / 62卷 / 10期

关键词：

Pancreatitis; idiopathic; Alcoholism; Gene mutations; Trypsin inhibitors; Calcium metabolism; HEREDITARY PANCREATITIS; VARIANTS; ALCOHOL; GENE; SPINK1; MUTATIONS; SMOKING; RISK; DEGRADATION; INHIBITOR;

D O I：

10.1007/s00108-021-01150-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Long-term alcohol consumption and gene mutations are the most important causes of chronic pancreatitis. In addition to mutations in acinar genes, such as digestive enzymes and their inhibitors, defects in genes that primarily or exclusively affect the duct cells have also been described in recent years. Genetic changes are found not only in patients with a positive family history (hereditary pancreatitis) but also in so-called idiopathic and, to a lesser extent, in alcoholic chronic pancreatitis. The coming years will likely show that there are very complex interactions between environmental influences and numerous genetic factors.

引用

页码：1007 / 1014

页数：8

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