Serum leptin levels are associated with the presence of syndesmophytes in male patients with ankylosing spondylitis

被引：0
作者：
Ki-Jo Kim
Ji-Young Kim
Su-Jung Park
Hosung Yoon
Chong-Hyeon Yoon
Wan-Uk Kim
Chul-Soo Cho
机构：
[1] The Catholic University of Korea,Division of Rheumatology, Department of Internal Medicine, College of Medicine
[2] The Catholic University of Korea,Division of Rheumatology, Department of Internal Medicine, Yeouido St. Mary’s Hospital
来源：
Clinical Rheumatology | 2012年 / 31卷
关键词：
Ankylosing spondylitis; Leptin; Syndesmophyte;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study is to clarify the association between serum leptin levels and the presence of syndesmophytes in male patients with ankylosing spondylitis (AS). Seventy-two male patients with AS and 20 age-matched healthy male controls were included. Patients were stratified by the presence of syndesmophytes. Serum leptin levels were measured and adjusted for body mass index (BMI). In addition, bone-specific alkaline phosphatase (BALP), osteocalcin, and telopeptide of type I collagen were determined. Patients with syndesmophytes were associated with older age (p < 0.001), longer disease duration (p = 0.003), and higher BMI (p = 0.038). Serum leptin levels and leptin per BMI (leptin/BMI) ratio were not different between AS patients and healthy controls. However, serum leptin/BMI ratio was significantly higher in patients with syndesmophytes compared to those without (p = 0.010). In multivariate analysis, higher serum leptin/BMI ratio remained significantly associated with the presence of syndesmophytes (p = 0.029). Moreover, serum leptin/BMI ratio was positively correlated with serum BALP (γ = 0.279, p = 0.039). However, there was no significant association between serum leptin/BMI ratio and bone mineral density. Serum leptin levels are elevated in male AS patients with syndesmophytes and were found to be correlated with bone formation marker, suggesting a potential role of leptin in new bone formation in AS.
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页码：1231 / 1238
页数：7
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