An efficient, one-pot three components synthesis of [1,2,4] triazoloquinazolinone derivatives using anthranilic acid as green catalyst

A simple, efficient and convenient approach has been reported for the synthesis of quinazolines by the condensation of 3-amino, 1,2,4-triazole with dimedone and different aromatic aldehydes in the presence of anthranilic acid as a catalyst through a one-pot reaction. The high yield, at low cost, with no need of chromatographic separation, and the environmentally friendly catalyst are the prominent features of this protocol. The zwitterion of anthranilic acid plays an important role in this one-pot reaction.