Treatment options for primary constipation

被引：10
作者：
Pampati V. [1 ]
Fogel R. [1 ]
机构：
[1] Division of Gastoenterology, Henry Ford Hospital, Detriot, MI 48202
来源：
Current Treatment Options in Gastroenterology | 2004年 / 7卷 / 3期
关键词：
Constipation; Irritable Bowel Syndrome; Main Side Effect; Main Drug Interaction; Tegaserod;
D O I：
10.1007/s11938-004-0043-z
中图分类号：
学科分类号：
摘要：
Patients suffering from primary constipation often show symptom improvement with increased intake of fiber. Bulk laxatives are a core component of treatment if dietary fiber is unsuccessful in alleviating symptoms. Although there are a number of commercial laxative preparations available, only polyethylene glycol (PEG), an osmotic laxative, should be used on a daily basis. For the elderly, saline laxatives may be used on a regular basis, provided there are no cardiac or renal comorbid contraindications. Tegaserod, a 5-HT4 partial receptor agonist, is approved for the treatment of constipation in female patients. The appropriate role of biofeedback remains to be determined. Surgery should be reserved for patients with slow transit constipation refractory to medical therapy. Patients being considered for surgery should be evaluated at institutions with substantial expertise in the investigation and management of this population. Copyright © 2004 by Current Science Inc.
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页码：225 / 233
页数：8
相关论文
共 42 条
  • [1] Lembo A., Camilleri M., Chronic constipation, N. Engl. J. Med, 349, pp. 1360-1368, (2003)
  • [2] Stewart R.B., Moore M.T., Marks R.G., Et al., Correlates of constipation in an ambulatory elderly population, Am. J. Gastroenterol., 87, pp. 859-864, (1992)
  • [3] Hale W.E., Perkins L.L., May F.E., Et al., Symptom prevalence in the elderly. An evalution of age, sex, disease, and medication use, J. Am. Geriatr. Soc., 34, pp. 335-340, (1986)
  • [4] Whitehead W.E., Drinkwater D., Cheskin L.J., Et al., Constipation in the elderly living at home. Definition, prevalence, and relationship to lifestyle and health status, J. Am. Geriatr. Soc., 37, pp. 423-429, (1989)
  • [5] Dukas L., Willett W.C., Giovannucci E.L., Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women, Am. J. Gastroenterol., 98, pp. 1790-1796, (2003)
  • [6] Bingham S.A., Cummings J.H., Effect of exercise and physical fitness on large intestinal function, Gastroenterology, 97, pp. 1389-1399, (1989)
  • [7] Oettle G.J., Effect of moderate exercise on bowel habit, Gut, 32, pp. 941-944, (1991)
  • [8] Coenen C., Wegener M., Wedmann B., Et al., Does physical exercise influence bowel transit time in healthy young men?, Am. J. Gastroenterol., 87, pp. 292-295, (1992)
  • [9] Velio P., Assotti G., Chronic idiopathic constipation: Pathophysiology and treatment, J. Clin. Gastroenterol., 22, pp. 190-196, (1996)
  • [10] Chung B.D., Parekh U., Sellin J.H., Effect of increased fluid intake on stool output in normal healthy volunteers, J. Clin. Gastroenterol., 28, pp. 29-32, (1999)
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