A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants

被引：0
作者：
Zhengwei Zhang
Jingjie Ge
Kai Jing
Yefeng Chen
Yihui Guan
Hexin Xie
Jianhua Zhu
机构：
[1] Fudan University,Department of Radiopharmacy, School of Pharmacy
[2] Fudan University,PET Center, Huashan Hospital
[3] East China University of Science and Technology,School of Pharmacy
来源：
Medicinal Chemistry Research | 2022年 / 31卷
关键词：
6-[; F]fluoro-L-DOPA; Radiosynthesis; Positron emission tomography; Congenital hyperinsulinism; Imaging;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
6-[18F]fluoro-L-DOPA is a radiotracer widely used in the diagnosis of a range of diseases, including neuro-oncology, endocrinology, and Parkinson’s disease. To meet the rapidly growing clinical need for this radioactive compound, this study reports an optimized radiosynthesis for this molecule, which proved to be highly reliable and compatible with different types of automated radiosynthesizers. Moreover, with 6-[18F]fluoro-L-DOPA, the PET/CT imaging of a total of 23 patients has been conducted, further demonstrating this radiotracer as a clinically valuable reagent to diagnose congenital hyperinsulinism (CHI) of infants in a non-invasive manner and, more importantly, localize the exact lesion on pancreas.
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页码：1126 / 1134
页数：8
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