Follicular Epithelial Dysplasia as Hashimoto Thyroiditis-Related Atypia: a Series of 91 Specimens

被引:0
作者
Ivana Kholová
David Kalfert
Jarkko Lintusaari
Erja Rajakorpi
Marie Ludvíková
机构
[1] Fimlab Laboratories,Faculty of Medicine and Health Technology
[2] Tampere University,Department of Otorhinolaryngology and Head and Neck Surgery, First Faculty of Medicine
[3] University Hospital Motol,Pathology Department
[4] Charles University,Department of Biology, Faculty of Medicine in Pilsen
[5] Seinäjoki Central Hospital,undefined
[6] Charles University,undefined
来源
Endocrine Pathology | 2021年 / 32卷
关键词
Follicular epithelial dysplasia; Hashimoto thyroiditis; Papillary thyroid carcinoma; Inflammation; Fine-needle aspiration; Cytohistologic discrepancy;
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学科分类号
摘要
Follicular epithelial dysplasia (FED) is described as Hashimoto thyroiditis-related atypia and is thought to be a possible precancerous lesion. Dysplasia as an interface between normal state and carcinoma is described in a wide range of diseases and carcinogenesis chains. On the other hand, inflammation-related atypia and cancerogenesis is also widely studied. In this study, we retrospectively analyzed 91 specimens of thyroid gland surgical resections with FED during a 10-year-period at the university hospital pathology department. The study population consisted of 68 females and 15 males aged between 22 and 86 years. The preoperative cytology diagnoses had mainly been in the indeterminate categories with prevailing AUS/FLUS results in the FED-only group (p = 0.005) and suspicious for malignancy and malignant in the group with FED plus adjacent malignancy. The decision for surgery was malignancy related in 48.2% of the cases. The lesions were sized 0.1–3.5 mm and multifocal in 45.1% of the cases. Immunohistochemically, the atypical cells were cyclin D1-positive in 67.5%, galectin-3 in 72.7%, CK19 in 85.7%, and HBME-1 in 87.0% of cases. In conclusion, FED is suggested to be a pathogenetic link between inflammation-related atypia and papillary carcinoma and thus a premalignant precursor of papillary carcinoma in HT as 36.1% of the specimens contained also papillary carcinoma in the present study. Both histopathological nuclear features and the immunoprofile of FED are widely shared with that of papillary carcinoma.
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页码:368 / 374
页数:6
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