Molecular determinants of folate levels after leucovorin administration in colorectal cancer

[11] Hoff PM(2008)Tissue levels of reduced folates in patients with colorectal carcinoma after infusion of folinic Acid at various dose levels Clin Cancer Res 14 7930-7934

[12] Skillings JR(2009)Oral fluoropyrimidine S-1 combined with leucovorin is a promising therapy for colorectal cancer: evidence from a xenograft model of folate-depleted mice Mol Med Rep 2 393-398

[13] Eisenberg P(1993)HPLC of folinic acid diastereoisomers and 5-methyltetrahydrofolate in plasma Clin Chem 39 82-86

[14] Davidson N(1994)High-performance liquid chromatographic determination of methotrexate, 7-hydroxymethotrexate, 5-methyltetrahydrofolic acid and folinic acid in serum and cerebrospinal fluid J Chromatogr B Biomed Appl 661 109-118

[15] Harper P(2007)A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule Clin Pharmacokinet 46 953-963

[16] Vincent MD(2001)New perspectives on folate catabolism Annu Rev Nutr 21 255-282

[17] Lembersky BC(2006)Gamma-glutamyl hydrolase and drug resistance Clin Chim Acta 374 25-32

[18] Thompson S(2008)Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity Biochem Biophys Res Commun 365 801-807

[19] Maniero A(2008)Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype Br J Cancer 98 1555-1561

[20] Benner SE(2006)The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis Drug Resist Updat 9 227-246

[11] Hoff PM(2008)Tissue levels of reduced folates in patients with colorectal carcinoma after infusion of folinic Acid at various dose levels Clin Cancer Res 14 7930-7934

[12] Skillings JR(2009)Oral fluoropyrimidine S-1 combined with leucovorin is a promising therapy for colorectal cancer: evidence from a xenograft model of folate-depleted mice Mol Med Rep 2 393-398

[13] Eisenberg P(1993)HPLC of folinic acid diastereoisomers and 5-methyltetrahydrofolate in plasma Clin Chem 39 82-86

[14] Davidson N(1994)High-performance liquid chromatographic determination of methotrexate, 7-hydroxymethotrexate, 5-methyltetrahydrofolic acid and folinic acid in serum and cerebrospinal fluid J Chromatogr B Biomed Appl 661 109-118

[15] Harper P(2007)A clinical pharmacokinetic analysis of tegafur-uracil (UFT) plus leucovorin given in a new twice-daily oral administration schedule Clin Pharmacokinet 46 953-963

[16] Vincent MD(2001)New perspectives on folate catabolism Annu Rev Nutr 21 255-282

[17] Lembersky BC(2006)Gamma-glutamyl hydrolase and drug resistance Clin Chim Acta 374 25-32

[18] Thompson S(2008)Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity Biochem Biophys Res Commun 365 801-807

[19] Maniero A(2008)Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype Br J Cancer 98 1555-1561

[20] Benner SE(2006)The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis Drug Resist Updat 9 227-246