Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons

被引：0
|
作者：
Jillian C Belrose
Yu-Feng Xie
Lynn J Gierszewski
John F MacDonald
Michael F Jackson
机构：
[1] University of Western Ontario,Department of Anatomy and Cell Biology
[2] University of Western Ontario,Robarts Research Institute, Molecular Brain Research Group
[3] University of Western Ontario,Department of Physiology and Pharmacology
[4] University of Western Ontario,Robarts Research Institute, Molecular Brain Research Group, Department of Physiology and Pharmacology
来源：
Molecular Brain | / 5卷
关键词：
TRPM2; Aging; Glutathione; Oxidative stress; Pyramidal neuron; Primary hippocampal culture;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 30 条
  • [1] Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons
    Belrose, Jillian C.
    Xie, Yu-Feng
    Gierszewski, Lynn J.
    MacDonald, John F.
    Jackson, Michael F.
    MOLECULAR BRAIN, 2012, 5
  • [2] Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death
    Li, Xin
    Yang, Wei
    Jiang, Lin-Hua
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2017, 10
  • [3] Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy
    Ying, Yingchao
    Gong, Lifen
    Tao, Xiaohan
    Ding, Junchao
    Chen, Nannan
    Yao, Yinping
    Liu, Jiajing
    Chen, Chen
    Zhu, Tao
    Jiang, Peifang
    MOLECULAR NEUROBIOLOGY, 2022, 59 (11) : 6918 - 6933
  • [4] Genetic Knockout of TRPM2 Increases Neuronal Excitability of Hippocampal Neurons by Inhibiting Kv7 Channel in Epilepsy
    Yingchao Ying
    Lifen Gong
    Xiaohan Tao
    Junchao Ding
    Nannan Chen
    Yinping Yao
    Jiajing Liu
    Chen Chen
    Tao Zhu
    Peifang Jiang
    Molecular Neurobiology, 2022, 59 : 6918 - 6933
  • [5] TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death
    Verma, S.
    Quillinan, N.
    Yang, Y. -F.
    Nakayama, S.
    Cheng, J.
    Kelley, M. H.
    Herson, P. S.
    NEUROSCIENCE LETTERS, 2012, 530 (01) : 41 - 46
  • [6] Glutathione Modulates Ca2+ Influx and Oxidative Toxicity Through TRPM2 Channel in Rat Dorsal Root Ganglion Neurons
    Naziroglu, Mustafa
    Ozgul, Cemil
    Cig, Bilal
    Dogan, Salih
    Uguz, Abdulhadi Cihangir
    JOURNAL OF MEMBRANE BIOLOGY, 2011, 242 (03): : 109 - 118
  • [7] Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells
    Armagan, Hamit Hakan
    Naziroglu, Mustafa
    CHEMICO-BIOLOGICAL INTERACTIONS, 2021, 334
  • [8] Glutathione Modulates Ca2+ Influx and Oxidative Toxicity Through TRPM2 Channel in Rat Dorsal Root Ganglion Neurons
    Mustafa Nazıroğlu
    Cemil Özgül
    Bilal Çiğ
    Salih Doğan
    Abdulhadi Cihangir Uğuz
    The Journal of Membrane Biology, 2011, 242 : 109 - 118
  • [9] Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons
    Li, Xin
    Jiang, Lin-Hua
    CELL DEATH & DISEASE, 2018, 9
  • [10] Multiple molecular mechanisms form a positive feedback loop driving amyloid β42 peptide-induced neurotoxicity via activation of the TRPM2 channel in hippocampal neurons
    Xin Li
    Lin-Hua Jiang
    Cell Death & Disease, 9
123