Molecular Chaperones, Alpha-Synuclein, and Neurodegeneration

被引：0
作者：
Stephan N. Witt
机构：
[1] Louisiana State University Health Sciences Center at Shreveport,Department of Biochemistry and Molecular Biology
来源：
Molecular Neurobiology | 2013年 / 47卷
关键词：
Alpha-synuclein; Cysteine string protein; Hsp40; Hsp70; Molecular chaperone; Neurodegeneration; Parkinson’s disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Parkinson’s disease (PD) is a devastating neurological condition that affects about 1 % of people older than 65 years of age. In PD, dopaminergic neurons in the mid-brain slowly accumulate cytoplasmic inclusions (Lewy bodies, LBs) of the protein alpha-synuclein (α-syn) and then gradually lose function and die off. Cell death is thought to be causally linked to the aggregation/fibrillization of α-syn. This review focuses on new findings about the structure of α-syn, about how α-syn cooperates with Hsp70 and Hsp40 chaperones to promote neurotransmitter release, and about cell-to-cell transfer of pathogenic forms of α-syn and how Hsp70 might protect against this disease process.
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页码：552 / 560
页数：8
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