Capsaicinoid-Glucosides of Fresh Hot Pepper Promotes Stress Resistance and Longevity in Caenorhabditis elegans

被引：0
作者：
Abdeen Elkhedir
Aamir Iqbal
Amgad Albahi
Mingfang Tao
Li Rong
Xiaoyun Xu
机构：
[1] Huazhong Agricultural University,Key Laboratory of Environment Correlative Dietology, Ministry of Education
[2] Cornell University,College of Agricultural and Life Science
来源：
Plant Foods for Human Nutrition | 2022年 / 77卷
关键词：
Capsaicinoid-glucosides; Oxidative stress; DAF-16/FOXO; SKN-1/Nrf2; Lifespan; UPLC-ESI-Q-TOF–MS/PDA;
D O I：
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中图分类号：
学科分类号：
摘要：
In this study, capsaicin-glucoside and dihydro-capsaicin-glucoside derived from fresh hot-red pepper were isolated and identified using UPLC-ESI-Q-TOF–MS/PDA. Synchronized worms were treated with capsaicinoid-glucosides (CG), and then lifespan and stress resistance were examined. The 50 µg/ml concentration of CG-intake could effectively protect the Caenorhabditis elegans (C. elegans) against stresses factors including oxidation and heat as well as reactive oxygen species (ROS), thereby enhancing the survival of CG-treated worms under stress. Enhancing stress resistance in CG-treated worms could be due to the increased expressions of stress-related genes in C. elegans such as daf-16, skn-1 and their downstream target genes (sod-3, hsp-16.2, gst-4 and gcs-1). Lifespan study of different C. elegans strains and RT-PCR showed that the CG-mediated lifespan extension was dependent on DAF-16/FOXO and SKN-1/Nrf2 transcription factors. The study is a step forward in exploring the stress resistance and anti-aging properties of this beneficial extract. Thus, this study will be useful in formulating remedies for stresses factors and age associated disorders.
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页码：30 / 36
页数：6
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