Nicotine self-administration in mice is associated with rates of nicotine inactivation by CYP2A5

被引:0
作者
Eric C. K. Siu
Dieter B. Wildenauer
Rachel F. Tyndale
机构
[1] University of Toronto,Centre for Addiction & Mental Health and the Department of Pharmacology
[2] University of Western Australia,Centre for Clinical Research in Neuropsychiatry
来源
Psychopharmacology | 2006年 / 184卷
关键词
Nicotine; Self-administration; Mice; CYP2A5; Nicotine C-oxidation; Genetics; Smoking;
D O I
暂无
中图分类号
学科分类号
摘要
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页码:401 / 408
页数:7
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[1]  
Aschhoff S(1999)Nicotine consumption of several mouse strains using a two bottle choice paradigm J Exp Anim Sci 40 171-177
[2]  
Schroff K-C(1985)Nicotine renal excretion rate influences nicotine intake during cigarette smoking J Pharmacol Exp Ther 234 153-155
[3]  
Wildenauer DB(1993)Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers Clin Pharmacol Ther 53 316-323
[4]  
Richter E(1994)Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine J Pharmacol Exp Ther 268 296-303
[5]  
Benowitz NL(1979)The enzyme “aldehyde oxidase” is an iminium oxidase. Reaction with nicotine delta 1′(5′) iminium ion Biochem Biophys Res Commun 91 991-996
[6]  
Jacob P(1985)Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation J Biol Chem 260 15357-15361
[7]  
Benowitz NL(1988)Genetic influences on acute responses to nicotine and nicotine tolerance in the mouse Pharmacol Biochem Behav 30 269-278
[8]  
Jacob P(1997)Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies Psychopharmacology (Berl) 132 107-124
[9]  
Benowitz NL(2001)Influence of gender and sex hormones on nicotine acute pharmacological effects in mice J Pharmacol Exp Ther 296 132-140
[10]  
Jacob P(2002)Accelerated metabolism of nicotine and cotinine in pregnant smokers J Pharmacol Exp Ther 301 594-598