Synthesis of new purine, pteridine, and other pyrimidine derivatives

被引：0
作者：
E. Abdel-Latif
H. M. Mustafa
H. A. Etman
A. A. Fadda
机构：
[1] University of Mansoura,Faculty of Science, Chemistry Department
来源：
Russian Journal of Organic Chemistry | 2007年 / 43卷
关键词：
Malononitrile; Pyrimidine Ring; Pteridine; Phenyl Isothiocyanate; Diethyl Malonate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The reaction of malononitrile dimer with phenyl isothiocyanate gave (6-amino-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-ylidene)malononitrile which was then used as starting material in the synthesis of pharmacologically important fused pyrimidine derivatives, such as 4-dicyanomethylidene-1,5-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrrolo[2,3-d]pyrimidine, 6-cyano-4-dicyanomethylidene-7-methylsulfanyl-5-oxo-1-phenyl-2-thioxo-1,2,3,4,5,8-hexahydropyrido[2,3-d]pyrimidine, 6-dicyanomethylidene-3-phenyl-2-thioxo-1,2,3,6-tetrahydro-9H-purine, and 6-substituted 4-dicyanomethylidene-7-oxo-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydropteridines.
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页码：443 / 448
页数：5
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