Radiotherapy in soft-tissue sarcoma of the extremities

被引:0
作者
R. Correa
J. Gómez-Millán
M. Lobato
A. Fernández
R. Ordoñez
C. Castro
Y. lupiañez
J. A. Medina
机构
[1] Hospital Universitario Virgen de la Victoria,Servicio de Oncología Radioterápica
来源
Clinical and Translational Oncology | 2018年 / 20卷
关键词
Soft-tissue sarcoma; Preoperative radiotherapy; Postoperative radiotherapy; Chemotherapy; Multikinase inhibitor; Conservative surgery;
D O I
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学科分类号
摘要
Sarcomas are an infrequent and heterogeneous group of neoplasia. Surgery with or without associated radiotherapy (RT) is the basic treatment for this type of tumour. To increase the therapeutic ratio (the index between cytotoxic effects in tumours and normal tissue complications with a certain dose of radiation), new advances are being investigated to increase local and distant control and to decrease the morbidity of the treatment. The aim of this review was to analyse the different strategies, based on technology and biology, which are being investigated to increase the therapeutic ratio of this disease
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页码:1127 / 1135
页数:8
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[1]  
Burningham A(2012)The epidemiology of sarcoma Clin Sarcoma Res 2 14-144
[2]  
Hong G(2010)Role of radiation therapy in the management of soft tissue sarcoma Cancer Forum 34 142-1733
[3]  
Markhede L(1982)A multivariate analysis of the prognosis after surgical treatment of malignant soft-tissue tumors Cancer 49 1721-3259
[4]  
Angervall B(1999)Long-term outcomes after function sparing surgery without radiotherapy for soft tissue sarcoma of the extremities and trunk J Clin Oncol 17 3252-241
[5]  
Stener EH(2012)Radiation therapy: neoadjuvant, adjuvant, or not at all Surg Oncol Clin N Am 21 215-315
[6]  
Baldini J(1982)The treatment of soft tissue sarcomas of the extremities: prospective randomized evaluation of (1) limb-sparing surgery plus radiation therapy compared with amputation and (2) the role of adjuvant chemotherapy Ann Surg 196 305-868
[7]  
Goldberg C(1996)Long-term results of a prospective randomized trial of adjuvant brachytherapy in soft tissue sarcoma J Clin Oncol 14 859-478
[8]  
Jenner TF(1996)Prognostic significance of a positive microscopic margin in high-risk extremity soft tissue sarcoma: implications for management J Clin Oncol 14 473-110
[9]  
DeLaney SA(1989)The effect of local recurrence on survival time in adult high-grade soft tissue sarcomas J Clin Epidemiol 42 105-2241
[10]  
Rosenberg J(2002)Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial Lancet 359 2235-1374