Transforming growth factor beta signaling functions during mammalian kidney development

被引：0
|
作者：
Mihai G. Dumbrava
Jon L. Lacanlale
Christopher J. Rowan
Norman D. Rosenblum
机构：
[1] The Hospital for Sick Children,Program in Developmental and Stem Cell Biology
[2] University of Toronto,Department of Laboratory Medicine and Pathobiology
[3] University of Toronto,Department of Physiology
[4] University of Toronto,Department of Paediatrics
[5] The Hospital for Sick Children,Division of Nephrology
来源：
Pediatric Nephrology | 2021年 / 36卷
关键词：
Transforming growth factor beta; Kidney development; Stroma; Nephron; Ureteric bud;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aberrant transforming growth factor beta (TGFβ) signaling during embryogenesis is implicated in severe congenital abnormalities, including kidney malformations. However, the molecular mechanisms that underlie congenital kidney malformations related to TGFβ signaling remain poorly understood. Here, we review current understanding of the lineage-specific roles of TGFβ signaling during kidney development and how dysregulation of TGFβ signaling contributes to the pathogenesis of kidney malformation.
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页码：1663 / 1672
页数：9
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