m6A-modified circRNAs: detections, mechanisms, and prospects in cancers

被引：0
作者：
Shiyi Qin
Qi Zhang
Yanhua Xu
Shuo Ma
Tianyi Wang
Yuejiao Huang
Shaoqing Ju
机构：
[1] Nantong University,Medical School of Nantong University
[2] Affiliated Hospital of Nantong University,Department of Laboratory Medicine
[3] Affiliated Tumor Hospital of Nantong University,Department of Medical Oncology
[4] Affiliated Hospital of Nantong University,Research Center of Clinical Medicine
来源：
Molecular Medicine | 2022年 / 28卷
关键词：
CircRNA; Non-coding RNAs; N6-methyladenosine; Metabolism; Cancers;
D O I：
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摘要：
Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N6-methyladenosine (m6A), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processes of various diseases. An increasing amount of evidence has suggested that m6A modification is common in circRNAs and is associated with their biological functions. This review summarizes the effects of m6A modification on circRNAs and their regulation mechanisms in cancers, providing some suggestions of m6A-modified circRNAs in cancer therapy.
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[1]  
Abakir A(2020)-methyladenosine regulates the stability of RNA:DNA hybrids in human cells Nat Genet 52 48-55
[2]  
Giles T(2015)HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events Cell 162 1299-1308
[3]  
Cristini A(2017)Nm6aViewer: software for the detection, analysis, and visualization of RNA 23 1493-1501
[4]  
Foster J(2014)-methyladenosine peaks from mA-seq/ME-RIP sequencing data Mol Cell 56 55-66
[5]  
Dai N(2018)circRNA biogenesis competes with pre-mRNA splicing RNA 24 815-827
[6]  
Starczak M(2021)Cardiac circRNAs arise mainly from constitutive exons rather than alternatively spliced exons Nat Commun 12 3778-D235
[7]  
Rubio-Roldan A(2022)Hakai is required for stabilization of core components of the mA mRNA methylation machinery Nucleic Acids Res 50 D231-607
[8]  
Li M(2015)MODOMICS: a database of RNA modification pathways BMC Genomics 16 454-4315
[9]  
Eleftheriou M(2019)Strand-specific RNA sequencing in Theranostics 9 588-3142
[10]  
Crutchley J(2019) malaria identifies developmentally regulated long non-coding RNA and circular RNA Nat Commun 10 4695-206
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