Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck

被引:0
作者
J M del Campo
R Hitt
P Sebastian
C Carracedo
D Lokanatha
J Bourhis
S Temam
D Cupissol
D De Raucourt
N Maroudias
C M Nutting
N Compton
D Midwinter
L Downie
N Biswas-Baldwin
I El-Hariry
K J Harrington
机构
[1] Vall d’Hebron Hospital,
[2] Hospital Universitario 12 de Octubre,undefined
[3] Medical College Regional Cancer Centre,undefined
[4] Instituto de Enfermedades de Neoplásicas,undefined
[5] Kidwai Memorial Institute of Oncology,undefined
[6] Hosur Road,undefined
[7] Bengaluru,undefined
[8] Karnataka 560029,undefined
[9] India,undefined
[10] Institut Gustave Roussy,undefined
[11] Le Centre Val d’Aurelle—Paul Lemarque,undefined
[12] Centre François Baclesse14000,undefined
[13] Appollonion Private Hospital,undefined
[14] The Royal Marsden Hospital,undefined
[15] GlaxoSmithKline,undefined
[16] (I E-H formerly of GlaxoSmithKline),undefined
来源
British Journal of Cancer | 2011年 / 105卷
关键词
epidermal growth factor receptor; lapatinib; squamous cell carcinoma;
D O I
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摘要
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页码:618 / 627
页数:9
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[1]  
Abidoye OO(2006)A phase II study of lapatinib (GW572016) in recurrent/metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN) J Clin Oncol 24 5568-2190
[2]  
Cohen EE(2007)Predictive and pharmacodynamic biomarker studies in tumor and skin tissue samples of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with erlotinib J Clin Oncol 25 2184-7356
[3]  
Wong SJ(2002)Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma Cancer Res 62 7350-2514
[4]  
Kozloff MF(2008)Biomarkers in early clinical trials: the committed and the skeptics Clin Cancer Res 14 2512-11
[5]  
Nattam SR(1999)Towards prediction and modulation of treatment response Radiother Oncol 50 1-20
[6]  
Stenson KM(2002)Epidermal growth factor receptor as a therapeutic target in head and neck cancer Semin Radiat Oncol 12 11-1074
[7]  
Blair EA(2008)A phase II study of lapatinib monotherapy in chemotherapy-refractory HER2-positive and HER2-negative advanced or metastatic breast cancer Ann Oncol 19 1068-543
[8]  
Day S(2008)A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses Breast Cancer Res Treat 112 533-25
[9]  
Dancey JE(2005)The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer Cancer Res 65 18-4176
[10]  
Vokes EE(2006)Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas J Clin Oncol 24 4170-8108