N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease

被引:0
作者
Xiong Wang
Jiazhao Xie
Lu Tan
Yanjun Lu
Na Shen
Jiaoyuan Li
Hui Hu
Huijun Li
Xiaoguang Li
Liming Cheng
机构
[1] Huazhong University of Science and Technology,Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College
[2] Guangxi Medical University,Departments of Pathophysiology
[3] Huazhong University of Science and Technology,Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College
[4] Huazhong University of Science and Technology,Hepatic Biliary Pancreatic Surgery Department, The Central Hospital of Wuhan, Tongji Medical College
[5] Huazhong University of Science and Technology,Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College
来源
Translational Neurodegeneration | / 12卷
关键词
Alzheimer’s disease; circRNA; Synaptic dysfunction; GluN2B; Ubiquitination;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 265 条
[1]  
Selkoe DJ(2002)Alzheimer's disease is a synaptic failure Science 298 789-791
[2]  
Tzioras M(2023)Synaptic degeneration in Alzheimer disease Nat Rev Neurol 19 19-38
[3]  
McGeachan RI(2022)The synapse as a treatment avenue for Alzheimer's Disease Mol Psychiatry 27 2940-2949
[4]  
Durrant CS(2019)An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations Nat Neurosci 22 1903-1912
[5]  
Spires-Jones TL(2015)Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity Nat Neurosci 18 603-610
[6]  
Peng L(2013)Circular RNAs are a large class of animal RNAs with regulatory potency Nature 495 333-338
[7]  
Bestard-Lorigados I(2023)Identification of circRNAs linked to Alzheimer's disease and related dementias Alzheimers Dement 19 3389-1062
[8]  
Song W(2019)Whole-transcriptome analysis of APP/PS1 mouse brain and identification of circRNA-miRNA-mRNA networks to investigate AD pathogenesis Mol Ther Nucleic Acids 18 1049-406
[9]  
Dube U(2022)ceRNA network analysis reveals AP-1 transcription factor components as potential biomarkers for Alzheimer's disease Curr Alzheimer Res 19 387-12996
[10]  
Del-Aguila JL(2023)circRNA from APP gene changes in Alzheimer's disease human brain Int J Mol Sci 24 5-2251