Synthesis and Biological Activity of 1,11-bis(6,7-Methylenedioxy- and 6,7-Dimethoxy-1,2,3,4-Tetrahydroisoquinolin-1-YL)Undecanes

被引：0

作者：

E. O. Terent′eva

A. Sh. Saidov

Z. S. Khashimova

N. E. Tseomashko

S. A. Sasmakov

D. M. Abdurakhmanov

V. I. Vinogradova

Sh. S. Azimova

机构：

[1] Academy of Sciences of the Republic of Uzbekistan,S. Yu. Yunusov Institute of the Chemistry of Plant Substances

[2] Samarkand State University,S. A. Sadykov Institute of Bioorganic Chemistry

[3] Academy of Sciences of the Republic of Uzbekistan,undefined

来源：

Chemistry of Natural Compounds | 2017年 / 53卷

关键词：

brassylic acid; homoveratrylamine; homopiperanylamine; -tetrahydroisoquinoline; cytotoxicity; MTT; HeLa; HEp-2; hepatocytes; antimicrobial activity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Two bis(tetrahydroisoquinoline) derivatives of undecane were synthesized from brassylic acid and 3,4-dimethoxy-(or methylenedioxy-)phenylethylamine. It was shown that 4a and 4b were highly cytotoxic for cancer-cell cultures and less toxic to healthy cells and exhibited noticeable antimicrobial activity against Gram-positive and Gram-negative bacteria and fungal strain Candida albicans. The antifungal activity of 4a exceeded that of the reference drug nystatin.

引用

页码：328 / 332

页数：4

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