Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction

被引：0

作者：

Wolfgang Lieb

Tanja Zeller

Massimo Mangino

Anika Götz

Peter Braund

Juergen J. Wenzel

Christian Horn

Carole Proust

Patrick Linsel-Nitschke

Philippe Amouyel

Petra Bruse

Dominique Arveiler

Inke R. König

Jean Ferrières

Andreas Ziegler

Anthony J. Balmforth

Alun Evans

Pierre Ducimetière

Francois Cambien

Christian Hengstenberg

Klaus Stark

Alistair S. Hall

Heribert Schunkert

Stefan Blankenberg

Nilesh J. Samani

Jeanette Erdmann

Laurence Tiret

机构：

[1] Universität zu Lübeck,Medizinische Klinik II

[2] Universität zu Lübeck,Institut für Humangenetik

[3] Johannes Gutenberg-University,Department of Medicine II

[4] Glenfield Hospital,Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing

[5] Universität zu Lübeck,Institut für Medizinische Biometrie und Statistik

[6] INSERM UMR S 525,Faculty of Medicine, Department of Epidemiology and Public Health

[7] Université Pierre et Marie Curie,Department of Epidemiology and Public Health

[8] INSERM U744,Klinik und Poliklinik für Innere Medizin II

[9] Louis Pasteur University,LIGHT

[10] INSERM U558,Faculté de Médecine

[11] Queen’s University,undefined

[12] INSERM,undefined

[13] UMR S 780,undefined

[14] Universität Regensburg,undefined

[15] University of Leeds,undefined

[16] INSERM U525,undefined

来源：

Journal of Molecular Medicine | 2008年 / 86卷

关键词：

Myocardial infarction; Coronary artery disease; Genetics; Polymorphism; LRP8;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD (1,377 with MI) patients and 2,938 controls from the Wellcome Trust Case Control Consortium (WTCCC) MI/CAD cohort, in 346 CAD patients and 351 controls from the AtheroGene study and in 295 men with incident CAD and 301 controls from the Prospective Epidemiological Study of MI study and found no evidence for association in any of the populations studied. In the WTCCC and the German MI Family studies, additional single-nucleotide polymorphisms in the LRP8 gene were analysed and displayed no evidence for association either.

引用

页码：1163 / 1170

页数：7

共 242 条

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