Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease

被引：0

作者：

Carlos P Fitzsimons

Emma van Bodegraven

Marijn Schouten

Roy Lardenoije

Konstantinos Kompotis

Gunter Kenis

Mark van den Hurk

Marco P Boks

Caroline Biojone

Samia Joca

Harry WM Steinbusch

Katie Lunnon

Diego F Mastroeni

Jonathan Mill

Paul J Lucassen

Paul D Coleman

Daniel LA van den Hove

Bart PF Rutten

机构：

[1] University of Amsterdam,Center for Neuroscience, Swammerdam Institute for Life Sciences

[2] Maastricht University,Department of Translational Neuroscience, School of Mental Health and Neuroscience (MHENS)

[3] University Medical Center Utrecht,Department Psychiatry, Brain Center Rudolf Magnus

[4] University of São Paulo,School of Pharmaceutical Sciences of Ribeirão Preto

[5] University of Exeter Medical School,RILD Level 4

[6] University of Exeter,Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience

[7] Maastricht University Medical Centre,undefined

来源：

Molecular Neurodegeneration | / 9卷

关键词：

Adult neurogenesis; Epigenetics; Alzheimer’s disease; DNA methylation; Histone modifications; MicroRNAs; Stem cell; Induced pluripotent stem cell;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.

引用

共 50 条

[1] Epigenetic regulation of adult neural stem cells: implications for Alzheimer's disease
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