Long-term intraperitoneal injection of lipopolysaccharide induces high expression of Id2 in the brain of mice

被引：0
|
作者：
Le-Yu Wang
Zeng-zhi Niu
Bian-xiang Hu
Jia-ming Wu
Xuan Jiang
Xiao-fang Hu
Wen-hua Huang
Jun Ouyang
Lei Yu
Xiao-Zhong Qiu
机构：
[1] Southern Medical University,Department of Anatomy
来源：
Molecular Biology Reports | 2011年 / 38卷
关键词：
Lipopolysaccharide; Id2; NF-kappaB; Brain;
D O I：
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学科分类号：
摘要：
Lipopolysaccharide (LPS) from gram negative bacteria plays an important role in the pathophysiology of neurodegenerative diseases. Many evidences showed that LPS-induced neuroinflammation is related to upregulation of NF-kappaB. Here, we report that long-term treatment of lower dosage LPS mainly causes upregulation of Id2 protein. As an inhibitor of cell differentiation, Id2 plays an import role in adult olfactory neurogenesis. However, Id2 protein in brain acts as two edges in a sword, persist over-expression of Id2 in brain can induce neurodamages and may be related to neurodegeneration.
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页码：4193 / 4196
页数：3
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