New boron-containing 2′-deoxyadenosines

被引：0
作者：
A. A. Ilinova
V. I. Bregadze
A. N. Bogomazova
I. A. Lobanova
A. F. Mironov
A. A. Semioshkin
机构：
[1] Russian Academy of Sciences,A. N. Nesmeyanov Institute of Organoelement Compounds
[2] M. V. Lomonosov Moscow State University of Fine Chemical Technologies,N. I. Vavilov Institute of General Genetics
[3] Russian Academy of Sciences,undefined
来源：
Russian Chemical Bulletin | 2013年 / 62卷
关键词：
-dodecaborate; cobalt bis(1,2-dicarbollide); nucleosides; 2′-deoxyadenosine; conjugates; cytotoxicity;
D O I：
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学科分类号：
摘要：
Conjugates of polyhedral boron hydrides with deoxyadenosine were synthesized by the opening of cyclic oxonium derivatives of closo-dodecaborate and cobalt bis(1,2-dicarbollide) with 2′-deoxyadenosine derivatives containing a nucleophilic group in the substituent at C(8). Biological studies of the derivatives obtained for cytotoxicity revealed that the derivatives based on closo-dodecaborate did not exhibit cytotoxicity. The conjugates obtained can be used in further biological trials as potential agents for boron neutron capture therapy of cancer.
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页码：1115 / 1119
页数：4
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