Investigating T-cell memory

被引：0
|
作者：
Alberto Mantovani
机构：
[1] Istituto di Ricerche Farmacologiche ‘Mario Negri’,Department of Biotechnology
[2] Section of General Pathology University of Brescia,undefined
来源：
Nature | 2000年 / 407卷
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摘要：
Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore1 have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results1,2. I suggest that the particular enzyme (human placental alkaline phosphatase) chosen for irreversible marking in postnatal life contributes to certain features of this system and perturbs the homeostatic mechanisms of T-cell activation and death.
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页码：40 / 40
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