Investigating T-cell memory

被引：0
|
作者：
Alberto Mantovani
机构：
[1] Istituto di Ricerche Farmacologiche ‘Mario Negri’,Department of Biotechnology
[2] Section of General Pathology University of Brescia,undefined
来源：
Nature | 2000年 / 407卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Memory is a long-recognized, crucial and poorly understood property of adaptive immunity. Jacob and Baltimore1 have designed an elegant genetic approach to marking memory T cells and their precursors irreversibly and have obtained intriguing results1,2. I suggest that the particular enzyme (human placental alkaline phosphatase) chosen for irreversible marking in postnatal life contributes to certain features of this system and perturbs the homeostatic mechanisms of T-cell activation and death.
引用
收藏
页码：40 / 40
相关论文
共 50 条
  • [31] The descent of memory T-cell subsets
    Lefrancois, Leo
    Marzo, Amanda
    NATURE REVIEWS IMMUNOLOGY, 2006, 6 (08) : 618 - 623
  • [32] T-cell memory - Less is more
    Bird, L
    NATURE REVIEWS IMMUNOLOGY, 2006, 6 (04) : 258 - 259
  • [33] The who's who of T-cell differentiation: Human memory T-cell subsets
    Mahnke, Yolanda D.
    Brodie, Tess M.
    Sallusto, Federica
    Roederer, Mario
    Lugli, Enrico
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (11) : 2797 - 2809
  • [34] EFFECTOR T-CELL INDUCTION AND T-CELL MEMORY VERSUS PERIPHERAL DELETION OF T-CELLS
    ZINKERNAGEL, RM
    MOSKOPHIDIS, D
    KUNDIG, T
    OEHEN, S
    PIRCHER, H
    HENGARTNER, H
    IMMUNOLOGICAL REVIEWS, 1993, 133 : 199 - 223
  • [35] Modelling T-cell memory by genetic marking of memory T cells in vivo
    Joshy Jacob
    David Baltimore
    Nature, 1999, 399 : 593 - 597
  • [36] Modelling T-cell memory by genetic marking of memory T cells in vivo
    Jacob, J
    Baltimore, D
    NATURE, 1999, 399 (6736) : 593 - 597
  • [37] Investigating the role of integrins ανβ6 and ανβ8 in CD8+resident memory T-Cell and langerhan cell migration
    Diaz, J. S. De La Cruz
    Kaplan, D. H.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (05) : S18 - S18
  • [38] DIFFERENTIATION OF T-CELL LYMPHOKINE GENE-EXPRESSION - THE INVITRO ACQUISITION OF T-CELL MEMORY
    EHLERS, S
    SMITH, KA
    JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (01): : 25 - 36
  • [39] ACQUISITION OF T-CELL MEMORY PHENOTYPE IN MAN
    LEE, J
    HAYWARD, A
    CLINICAL RESEARCH, 1990, 38 (01): : A215 - A215
  • [40] Defining the Molecular Hallmarks of T-Cell Memory
    Zebley, Caitlin C.
    Akondy, Rama S.
    Youngblood, Benjamin A.
    Kissick, Haydn T.
    COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2022, 14 (03):
12345