Regulation of Telomerase Activity

被引：0
|
作者：
D. S. Nalobin
A. A. Galiakberova
S. I. Alipkina
A. I. Glukhov
机构：
[1] Moscow State University,
[2] Sechenov First Moscow State Medical University,undefined
来源：
Biology Bulletin Reviews | 2018年 / 8卷 / 2期
关键词：
telomere; telomerase; activity regulation; telomerase functions; telomerase complex genes;
D O I：
10.1134/S2079086418020068
中图分类号：
学科分类号：
摘要：
The published data on the regulation of telomerase activity are systemized. The structure and functions of telomeres and telomerase are described. The main pathways of epigenetic regulation of telomerase activity—modification of the TERT (telomerase reserve transcriptase) gene histone and its methylation— are described. Particular attention is paid to the regulation of telomerase activity at the transcriptional level (transcriptional activators and inhibitors of TERT, as well as two-way transcription regulators) and posttranscriptional regulation (alternative splicing of TERT mRNA, phosphorylation, and ubiquitination of TERT).
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页码：142 / 154
页数：12
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