Spontaneous migraine attack causes alterations in default mode network connectivity: A resting-state fMRI case report

被引：12
作者：
Edes A.E. [1 ,2 ,3 ]
Kozak L.R. [1 ,4 ]
Magyar M. [1 ,5 ]
Zsombok T. [1 ,2 ,5 ]
Kokonyei G. [1 ,2 ,6 ]
Bagdy G. [2 ,3 ,7 ]
Juhasz G. [1 ,2 ,3 ,8 ]
机构：
[1] MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group, Hungarian Academy of Sciences, Semmelweis University, Nagyvárad Square 4, Budapest
[2] MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Nagyvárad Square 4, Budapest
[3] Department of Pharmacodynamics, Faculty of Pharmacy, Semmelweis University, Nagyvárad Square 4, Budapest
[4] MR Research Center, Semmelweis University, Balassa Street 6, Budapest
[5] Department of Neurology, Faculty of Medicine, Semmelweis University, Balassa Street 6, Budapest
[6] Institute of Psychology, Eotvos Lorand University, Izabella Street 46, Budapest
[7] NAP-A-SE Research Group, Hungarian Academy of Sciences, Semmelweis University, Nagyvárad Square 4, Budapest
[8] Neuroscience and Psychiatry Unit, Manchester Academic Health Sciences Centre, University of Manchester, Stopford Building, Oxford Road, Manchester
来源：
BMC Research Notes | / 10卷 / 1期
关键词：
Case report; Functional connectivity; Headache pain; Migraine; Migraine attack; Neuroimaging; Pain processing;
D O I：
10.1186/s13104-017-2484-1
中图分类号：
学科分类号：
摘要：
Background: Although migraine is one of the most investigated neurologic disorders, we do not have a perfect neuroimaging biomarker for its pathophysiology. One option to improve our knowledge is to study resting-state functional connectivity in and out of headache pain. However, our understanding of the functional connectivity changes during spontaneous migraine attack is partial and incomplete. Case presentation: Using resting-state functional magnetic resonance imaging we assessed a 24-year old woman affected by migraine without aura at two different times: during a spontaneous migraine attack and in interictal phase. Seed-to-voxel whole brain analysis was carried out using the posterior cingulate cortex as a seed, representing the default mode network (DMN). Our results showed decreased intrinsic connectivity within core regions of the DMN with an exception of a subsystem including the dorsal medial and superior frontal gyri, and the mid-temporal gyrus which is responsible for pain interpretation and control. In addition, increased connectivity between the DMN and pain and specific migraine-related areas, such as the pons and hypothalamus, developed during the spontaneous migraine attack. Conclusion: Our preliminary results provide further support for the hypothesis that alterations of the DMN functional connectivity during migraine headache may lead to maladaptive top-down modulation of migraine pain-related areas which might be a specific biomarker for migraine. © 2017 The Author(s).
引用
收藏
相关论文
共 13 条
[1]  
Mainero C., Boshyan J., Hadjikhani N., Altered functional magnetic resonance imaging resting-state connectivity in periaqueductal gray networks in migraine, Ann Neurol, 70, 5, pp. 838-845, (2011)
[2]  
Kucyi A., Davis K.D., The dynamic pain connectome, Trends Neurosci, 38, 2, pp. 86-95, (2015)
[3]  
Baliki M.N., Mansour A.R., Baria A.T., Apkarian A.V., Functional reorganization of the default mode network across chronic pain conditions, PLoS ONE, 9, 9, (2014)
[4]  
Amin F.M., Hougaard A., Magon S., Asghar M.S., Ahmad N.N., Rostrup E., Et al., Change in brain network connectivity during PACAP38-induced migraine attacks: A resting-state functional MRI study, Neurology, 86, 2, pp. 180-187, (2016)
[5]  
Bes A., Kunkel R., Lance J.W., Nappi G., Pfaffenrath V., Rose F.C., Et al., The international classification of headache disorders, 3rd edition (beta version), Cephalalgia, 33, 9, pp. 629-808, (2013)
[6]  
Zhao L., Liu J., Yan X., Dun W., Yang J., Huang L., Et al., Abnormal brain activity changes in patients with migraine: A short-term longitudinal study, J Clin Neurol, 10, 3, pp. 229-235, (2014)
[7]  
Tracey I., Imaging pain, Brit J Anaesth, 101, 1, pp. 32-39, (2008)
[8]  
Tessitore A., Russo A., Giordano A., Conte F., Corbo D., De Stefano M., Et al., Disrupted default mode network connectivity in migraine without aura, J Headache Pain, 14, (2013)
[9]  
Kucyi A., Salomons T.V., Davis K.D., Mind wandering away from pain dynamically engages antinociceptive and default mode brain networks, Proc Natl Acad Sci USA, 110, 46, pp. 18692-18697, (2013)
[10]  
Kucyi A., Moayedi M., Weissman-Fogel I., Goldberg M.B., Freeman B.V., Tenenbaum H.C., Et al., Enhanced medial prefrontal-default mode network functional connectivity in chronic pain and its association with pain rumination, J Neurosci, 34, 11, pp. 3969-3975, (2014)
12