Sulfation of Betulin by Sulfamic Acid in DMF and Dioxane

被引：0
作者：
V. A. Levdanskii
A. V. Levdanskii
B. N. Kuznetsov
机构：
[1] Russian Academy of Sciences,Institute of Chemistry and Chemical Technology, Siberian Branch
[2] Siberian Federal University,undefined
来源：
Chemistry of Natural Compounds | 2014年 / 50卷
关键词：
betulin; 1,4-dioxane; ,; -dimethylformamide; sulfation; betulin 3,28-disulfate; urea; sulfamic acid;
D O I：
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学科分类号：
摘要：
Betulin was sulfated by sulfamic acid in the presence of urea in homogeneous solution in 1,4-dioxane or N,N-dimethylformamide (DMF). The reaction time for betulin sulfation in DMF at 60–70°C was 2.0–3.0 h; in 1,4-dioxane at 70–75°C, 3.0–3.5 h. Betulin disulfate was obtained in the acidic form and as the ammonium, sodium, and potassium salts.
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页码：1029 / 1031
页数：2
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