Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis

被引:0
|
作者
Queting Chen
Yong Li
Zhong Li
Qun Zhao
Liqiao Fan
机构
[1] The Fourth Affiliated Hospital of Hebei Medical University,Department of General Surgery
[2] Affiliated Hospital of Hebei University,Department of Surgical Oncology
来源
Journal of Molecular Histology | 2014年 / 45卷
关键词
PTP1B; Human colorectal cancer; Tumor progression; Prognosis;
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学科分类号
摘要
Protein tyrosine phosphatase 1B (PTP1B) is a non-transmembrane protein tyrosine phosphatase that has been implicated in cancer pathogenesis. However, the expression level and the role of PTP1B in the development and prognosis of colorectal cancer (CRC) remain unclear. In this study, the expression of PTP1B in CRC tissues and matched noncancerous tissues were detected by using immunohistochemistry, real-time PCR and Western blotting. The correlations between PTP1B expression level and clinicopathologic characteristics and patient survival were analyzed. We found that PTP1B expression was significantly higher in CRC tissues compared with matched non-tumour tissues. Statistical analysis showed that the PTP1B expression was correlated with tumor differentiation, tumor invasion, lymph node metastasis, and TNM stage. Patients with higher expressions of PTP1B had the lower survival (P = 0.012). Taken together, our results suggest that PTP1B expression might play a critical role in the progression of CRC and may serve as a valuable prognostic biomarker for CRC.
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页码:153 / 159
页数:6
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