Overexpression of PTP1B in human colorectal cancer and its association with tumor progression and prognosis
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作者:
Queting Chen
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机构:The Fourth Affiliated Hospital of Hebei Medical University,Department of General Surgery
Queting Chen
Yong Li
论文数: 0引用数: 0
h-index: 0
机构:The Fourth Affiliated Hospital of Hebei Medical University,Department of General Surgery
Yong Li
Zhong Li
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h-index: 0
机构:The Fourth Affiliated Hospital of Hebei Medical University,Department of General Surgery
Zhong Li
Qun Zhao
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h-index: 0
机构:The Fourth Affiliated Hospital of Hebei Medical University,Department of General Surgery
Qun Zhao
Liqiao Fan
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h-index: 0
机构:The Fourth Affiliated Hospital of Hebei Medical University,Department of General Surgery
Liqiao Fan
机构:
[1] The Fourth Affiliated Hospital of Hebei Medical University,Department of General Surgery
[2] Affiliated Hospital of Hebei University,Department of Surgical Oncology
来源:
Journal of Molecular Histology
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2014年
/
45卷
关键词:
PTP1B;
Human colorectal cancer;
Tumor progression;
Prognosis;
D O I:
暂无
中图分类号:
学科分类号:
摘要:
Protein tyrosine phosphatase 1B (PTP1B) is a non-transmembrane protein tyrosine phosphatase that has been implicated in cancer pathogenesis. However, the expression level and the role of PTP1B in the development and prognosis of colorectal cancer (CRC) remain unclear. In this study, the expression of PTP1B in CRC tissues and matched noncancerous tissues were detected by using immunohistochemistry, real-time PCR and Western blotting. The correlations between PTP1B expression level and clinicopathologic characteristics and patient survival were analyzed. We found that PTP1B expression was significantly higher in CRC tissues compared with matched non-tumour tissues. Statistical analysis showed that the PTP1B expression was correlated with tumor differentiation, tumor invasion, lymph node metastasis, and TNM stage. Patients with higher expressions of PTP1B had the lower survival (P = 0.012). Taken together, our results suggest that PTP1B expression might play a critical role in the progression of CRC and may serve as a valuable prognostic biomarker for CRC.
机构:
Hebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R China
Chen, Queting
Li, Yong
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机构:
Hebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R China
Li, Yong
Li, Zhong
论文数: 0引用数: 0
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机构:
Hebei Univ, Affiliated Hosp, Dept Surg Oncol, Baoding 071000, Hebei, Peoples R ChinaHebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R China
Li, Zhong
Zhao, Qun
论文数: 0引用数: 0
h-index: 0
机构:
Hebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R China
Zhao, Qun
Fan, Liqiao
论文数: 0引用数: 0
h-index: 0
机构:
Hebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Med Univ, Affiliated Hosp 4, Dept Gen Surg, Shijiazhuang 050011, Hebei, Peoples R China
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Yu, Hongyan
Meng, Xiangqi
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Meng, Xiangqi
Wu, Jiangxue
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Wu, Jiangxue
Pan, Changchuan
论文数: 0引用数: 0
h-index: 0
机构:
Second Peoples Hosp Sichuan Prov, Sichuan Canc Hosp & Inst, Chengdu, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Pan, Changchuan
Ying, Xiaofang
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Ying, Xiaofang
Zhou, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Zhou, Yi
Liu, Ranyi
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Liu, Ranyi
Huang, Wenlin
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R ChinaSun Yat Sen Univ, Ctr Canc, State Key Lab Oncol South China, Guangzhou 510275, Guangdong, Peoples R China
机构:
Southern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R ChinaSouthern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R China
Wang, Lifeng
Qi, Jia
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机构:
Southern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R ChinaSouthern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R China
Qi, Jia
Yu, Jinlong
论文数: 0引用数: 0
h-index: 0
机构:
Southern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R ChinaSouthern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R China
Yu, Jinlong
Chen, Haijin
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h-index: 0
机构:
Southern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R ChinaSouthern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R China
Chen, Haijin
Zou, Zhaowei
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机构:
Southern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R ChinaSouthern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R China
Zou, Zhaowei
Lin, Xiaohua
论文数: 0引用数: 0
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机构:
Southern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R ChinaSouthern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R China
Lin, Xiaohua
Guo, Linlang
论文数: 0引用数: 0
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机构:
Southern Med Univ, Zhujiang Hosp, Dept Pathol, Guangzhou 510280, Guangdong, Peoples R ChinaSouthern Med Univ, Zhujiang Hosp, Dept Gen Surg, 253 Ind Ave, Guangzhou 510280, Guangdong, Peoples R China
机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Guangdong Prov Key Lab Mol Tumor Pathol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Meng, Hui-Min
Zheng, Ping
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机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Guangdong Prov Key Lab Mol Tumor Pathol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Zheng, Ping
Wang, Xiao-Yan
论文数: 0引用数: 0
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机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Guangdong Prov Key Lab Mol Tumor Pathol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Wang, Xiao-Yan
Liu, Chao
论文数: 0引用数: 0
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机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Liu, Chao
Sui, Hong-Mei
论文数: 0引用数: 0
h-index: 0
机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Sui, Hong-Mei
Wu, Shao-Jie
论文数: 0引用数: 0
h-index: 0
机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Wu, Shao-Jie
Zhou, Jun
论文数: 0引用数: 0
h-index: 0
机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Zhou, Jun
Ding, Yan-Qing
论文数: 0引用数: 0
h-index: 0
机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Guangdong Prov Key Lab Mol Tumor Pathol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Ding, Yan-Qing
Li, Jian-Ming
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机构:
So Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
Guangdong Prov Key Lab Mol Tumor Pathol, Guangzhou, Guangdong, Peoples R ChinaSo Med Univ, Dept Pathol, Sch Basic Med Sci, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
机构:
Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South KoreaCatholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South Korea
Kim, Sang Woo
Jung, Chan Kwon
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Catholic Univ Korea, Dept Hosp Pathol, Coll Med, Seoul 137701, South KoreaCatholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South Korea
Jung, Chan Kwon
Cho, Yu Kyung
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Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South KoreaCatholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South Korea
Cho, Yu Kyung
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机构:
Lee, In Seok
Choi, Myung-Gyu
论文数: 0引用数: 0
h-index: 0
机构:
Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South KoreaCatholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South Korea
Choi, Myung-Gyu
Choi, Kyu Yong
论文数: 0引用数: 0
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机构:
Catholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South KoreaCatholic Univ Korea, Dept Internal Med, Coll Med, Seoul 137701, South Korea