The role of microRNA in esophageal squamous cell carcinoma

被引：0
|
作者：
Kazuto Harada
Yoshifumi Baba
Takatsugu Ishimoto
Hironobu Shigaki
Keisuke Kosumi
Naoya Yoshida
Masayuki Watanabe
Hideo Baba
机构：
[1] Kumamoto University,Department of Gastroenterological Surgery, Graduate School of Medical Science
[2] Japanese Foundation for Cancer Research,Department of Gastroenterological Surgery, Cancer Institute Hospital
来源：
Journal of Gastroenterology | 2016年 / 51卷
关键词：
MicroRNA; Esophageal squamous cell carcinoma; Biomarkers; Therapeutic targets; Review;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
MicroRNAs (miRNA) are 22-nucleotide non-coding RNAs that post-transcriptionally regulate gene expression by base pairing to partially complementary sequences in the 3′-untranslated region of their target messenger RNA. Altered miRNA expression also changes the expression of oncogenes and tumor suppressors, affecting the proliferation, apoptosis, motility and invasibility of gastrointestinal cancer cells, including the cells of esophageal squamous cell carcinoma (ESCC). It has been suggested that various miRNA expression profiles may provide useful biomarkers and therapeutic targets, but to date few studies have been published on the role of miRNA in ESCC. In this review we summarize the identification and characterization of miRNAs involved in ESCC and discuss their potential as biomarkers and therapeutic targets.
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页码：520 / 530
页数：10
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