A general review of major global coagulation assays: Thrombelastography, thrombin generation test and clot waveform analysis

被引：146
作者：
Lancé M.D. [1 ]
机构：
[1] Maastricht University Medical Center, Department of Anesthesiology and Pain Treatment, P. Debyelaan 25, PO box 5800, Maastricht, AZ
来源：
Thrombosis Journal | / 13卷 / 1期
关键词：
Global coagulation assays; Hemophilia; Hemorrhage; Thrombosis;
D O I：
10.1186/1477-9560-13-1
中图分类号：
学科分类号：
摘要：
Thrombosis and hemorrhage are major contributors to morbidity and mortality. The traditional laboratory tests do not supply enough information to diagnose and treat patients timely and according to their phenotype. Global hemostasis tests might improve this circumstance. The viscoelastic tests (ROTEM/TEG) demonstrated to ameliorate treatment of acute hemorrhage in terms of decreased amount of transfusion and lowered costs. Thrombin generation measurement is indicative for thrombosis and might also become an important tool in managing hemorrhage. While the clot waveform analysis is less well known it could be of worth in staging sepsis patients, early detection of DIC and also in diagnosis and treatment monitoring of hemophiliac patients. Although in different degree all three methods still need more background, standardization and acceptance before a wide clinical application. © Lancé licensee BioMed Central.
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共 58 条
[1]  
The top 10 causes of death, (2012)
[2]  
Kitchens C.S., To bleed or not to bleed? Is that the question for the PTT?, J Thromb Haemost, 3, pp. 2607-2611, (2005)
[3]  
Segal J.B., Dzik W.H., Paucity of studies to support that abnormal coagulation test results predict bleeding in the setting of invasive procedures: an evidence-based review, Transfusion, 45, pp. 1413-1425, (2005)
[4]  
Kozek-Langenecker S.A., Afshari A., Albaladejo P., Santullano C.A., De Robertis E., Filipescu D.C., Fries D., Gorlinger K., Haas T., Imberger G., Jacob M., Lance M., Llau J., Mallett S., Meier J., Rahe-Meyer N., Samama C.M., Smith A., Solomon C., Van der Linden P., Wikkelso A.J., Wouters P., Wyffels P., Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology, Eur J Anaesthesiol, 30, pp. 270-382, (2013)
[5]  
Spahn D.R., Bouillon B., Cerny V., Coats T.J., Duranteau J., Fernandez-Mondejar E., Filipescu D., Hunt B.J., Komadina R., Nardi G., Neugebauer E., Ozier Y., Riddez L., Schultz A., Vincent J.L., Rossaint R., Management of bleeding and coagulopathy following major trauma: an updated European guideline, Crit Care, 17, (2013)
[6]  
Hartert H., Blutgerinnungsstudien mit der Thromboelastographie: einem neuen Untersuchungsverfahren, Klin Wochenschr, 26, pp. 577-583, (1948)
[7]  
Macfarlane R.G., Biggs R., A thrombin generation test
[8]  
the application in haemophilia and thrombocytopenia, J Clin Pathol, 6, pp. 3-8, (1953)
[9]  
Holzknecht F., Die Auswertungen des Thromboelastogramms., (1962)
[10]  
Strassner H., Die Entwicklung der Thromboelastographie ans Messverfahren, (2002)
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