Brain serotonin metabolism during water deprivation and hydration in rats

被引：19

作者：

Popova N.K. ^{[1
]}

Ivanova L.N. ^{[1
]}

Amstislavskaya T.G. ^{[1
]}

Melidi N.N. ^{[1
]}

Naumenko K.S. ^{[1
]}

Maslova L.N. ^{[1
]}

Bulygina V.V. ^{[1
]}

机构：

[1] Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 630090 Novosibirsk

来源：

Neuroscience and Behavioral Physiology | 2001年 / 31卷 / 3期

基金：

俄罗斯基础研究基金会;

关键词：

Hydration; Renal concentrating function; Water deprivation;

D O I：

10.1023/A:1010346904526

中图分类号：

学科分类号：

摘要：

The effects of two-day water deprivation and hyperhydration (provision of 4% sucrose solution for 48 h) on levels of serotonin and its major metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the midbrain and hypothalamus were studied in Wistar rats. The rates of diuresis (0.05 ± 0.01 and 0.84 ± 0.12 ml/h/100 g in water deprivation and hyperhydration respectively) and urine osmolality (1896 ± 182 and 50 ± 13 mOsm/kg) reflected increases and decreases in blood vasopressin levels. Water deprivation was associated with a significant increase in 5-HIAA levels in the midbrain and hypothalamus, along with a decrease in serotonin levels and a three-fold increase in serotonin catabolism (the 5-HIAA:serotonin concentration ratio). Hyperhydration induced moderate increases in serotonin and 5-HIAA levels in the hypothalamus with no changes in the midbrain. The blood corticosterone level doubled in water deprivation and decreased in hyperhydration. It is suggested that activation of the serotoninergic system induces a complex adaptive reaction in water deprivation, including mechanisms specific for the regulation of water-electrolyte homeostasis and non-specific stress mechanisms (vasopressin and corticoliberin secretion).

引用

页码：327 / 332

页数：5

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