Human T-cell leukemia virus type 1 (HTLV-1) and leukemic transformation: viral infectivity, Tax, HBZ and therapy

被引：0
作者：
M Matsuoka
K-T Jeang
机构：
[1] Institute for Virus Research,
[2] Kyoto University,undefined
[3] Molecular Virology Section,undefined
[4] Laboratory of Molecular Microbiology,undefined
[5] the National Institute of Allergy and Infectious Diseases,undefined
[6] National Institutes of Health,undefined
来源：
Oncogene | 2011年 / 30卷
关键词：
human T-cell leukemia virus type 1 (HTLV-1); adult T-cell leukemia (ATL); Tax; HTLV-1 bZIP factor (HBZ); aneuploidy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus discovered to be causative of a human cancer, adult T-cell leukemia. The transforming entity of HTLV-1 has been attributed to the virally-encoded oncoprotein, Tax. Unlike the v-onc proteins encoded by other oncogenic animal retroviruses that transform cells, Tax does not originate from a c-onc counterpart. In this article, we review progress in our understanding of HTLV-1 infectivity, cellular transformation, anti-sense transcription and therapy, 30 years after the original discovery of this virus.
引用
收藏
页码：1379 / 1389
页数：10
相关论文
共 786 条
[1]  
Akagi T(1996)Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines: possible involvement of Tax1 in the altered expression of cyclin D2, p18Ink4 and p21Waf1/Cip1/Sdi1 Oncogene 12 1645-1652
[2]  
Ono H(2000)HTLV-1 tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration Oncogene 19 1491-1499
[3]  
Shimotohno K(2008)Human T-cell leukemia virus type-1 antisense-encoded gene, Hbz, promotes T-lymphocyte proliferation Blood 112 3788-3797
[4]  
Ariumi Y(2010)Hematopoietic stem cells and retroviral infection Retrovirology 7 8-3058
[5]  
Kaida A(2008)Human T-cell lymphotropic virus type 1 infection of CD34+ hematopoietic progenitor cells induces cell cycle arrest by modulation of p21(cip1/waf1) and survivin Stem Cells 26 3047-43627
[6]  
Lin JY(2003)The HBZ factor of human T-cell leukemia virus type I dimerizes with transcription factors JunB and c-Jun and modulates their transcriptional activity J Biol Chem 278 43620-4183
[7]  
Hirota M(2010)Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes J Clin Oncol 28 4177-32905
[8]  
Masui O(2010)The viral oncoprotein tax sequesters DNA-damage response factors by tethering MDC1 to chromatin J Biol Chem 285 32897-4917
[9]  
Yamaoka S(2009)Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia Blood 113 4914-9225
[10]  
Arnold J(2006)The role of NF-{kappa}B-1 and NF-{kappa}B-2-mediated resistance to apoptosis in lymphomas Proc Natl Acad Sci USA 103 9220-41
12345678910