Rationale Reward-associated cues can trigger incentive motivation for reward and invigorate reward-seeking behaviour via Pavlovian-to-instrumental transfer (PIT). Glutamate signaling within the basolateral amygdala (BLA) modulates cue-triggered increases in incentive motivation. However, the role of BLA metabotropic group II glutamate (mGlu(2/3)) receptors is largely unknown. Objectives In Experiment 1, we characterized cue-triggered increases in incentive motivation for water reward using the PIT paradigm. In Experiment 2, we assessed the influence of intra-BLA microinjections of the mGlu(2/3) receptor agonist LY379268 on this effect. Methods Water-restricted male Sprague-Dawley rats learned to press a lever for water. Separately, they learned to associate one of two auditory cues with free water. On test days, rats could lever press under extinction conditions (no water), with intermittent, non-contingent CS+ and CS- presentations. In Experiment 1, rats were tested under baseline conditions. In Experiment 2, rats received intra-BLA microinjections of LY379268 (0, 3 and 6 mu g/hemisphere) before testing. Results Across experiments, CS+, but not CS-, presentations increased water-associated lever pressing during testing, even though responding was reinforced neither by water nor the CS+. Intra-BLA LY379268 abolished both CS+ potentiated pressing on the water-associated lever and CS+ evoked conditioned approach to the site of water delivery. LY379268 did not influence locomotion or instrumental and Pavlovian response rates during intervals between CS presentations or during the CS-, indicating no motor effects. Conclusions mGlu(2/3) receptor activity in the BLA mediates cue-triggered potentiation of incentive motivation for reward, suppressing both cue-induced increases in instrumental pursuit of the reward and anticipatory approach behaviour.
机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Cannady, Reginald
Grondin, Julie J. M.
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Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Grondin, Julie J. M.
Fisher, Kristen R.
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Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Fisher, Kristen R.
Hodge, Clyde W.
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h-index: 0
机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Hodge, Clyde W.
Besheer, Joyce
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机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
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Univ Roma La Sapienza, Dipartimento Psicol, Rome, Italy
Natl Res Council Italy, Lab Computat Embodied Neurosci, Inst Cognit Sci & Technol, Via S Martino della Battaglia 44, I-00185 Rome, ItalyUniv Roma La Sapienza, Dipartimento Psicol, Rome, Italy
Cartoni, Emilio
Balleine, Bernard
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Univ Sydney, Behav Neurosci Lab, Brain & Mind Ctr, Sydney, NSW 2006, AustraliaUniv Roma La Sapienza, Dipartimento Psicol, Rome, Italy
Balleine, Bernard
Baldassarre, Gianluca
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Natl Res Council Italy, Lab Computat Embodied Neurosci, Inst Cognit Sci & Technol, Via S Martino della Battaglia 44, I-00185 Rome, ItalyUniv Roma La Sapienza, Dipartimento Psicol, Rome, Italy
机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Cannady, Reginald
Grondin, Julie J. M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Grondin, Julie J. M.
Fisher, Kristen R.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Fisher, Kristen R.
Hodge, Clyde W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Pharmacol, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Hodge, Clyde W.
Besheer, Joyce
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
Univ N Carolina, Curriculum Neurobiol, Chapel Hill, NC 27599 USA
Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USAUniv N Carolina, Bowles Ctr Alcohol Studies, Chapel Hill, NC 27599 USA
机构:
Univ Roma La Sapienza, Dipartimento Psicol, Rome, Italy
Natl Res Council Italy, Lab Computat Embodied Neurosci, Inst Cognit Sci & Technol, Via S Martino della Battaglia 44, I-00185 Rome, ItalyUniv Roma La Sapienza, Dipartimento Psicol, Rome, Italy
Cartoni, Emilio
Balleine, Bernard
论文数: 0引用数: 0
h-index: 0
机构:
Univ Sydney, Behav Neurosci Lab, Brain & Mind Ctr, Sydney, NSW 2006, AustraliaUniv Roma La Sapienza, Dipartimento Psicol, Rome, Italy
Balleine, Bernard
Baldassarre, Gianluca
论文数: 0引用数: 0
h-index: 0
机构:
Natl Res Council Italy, Lab Computat Embodied Neurosci, Inst Cognit Sci & Technol, Via S Martino della Battaglia 44, I-00185 Rome, ItalyUniv Roma La Sapienza, Dipartimento Psicol, Rome, Italy