Properties of Connexin26 Hemichannels Expressed in Xenopus Oocytes

被引:54
|
作者
Harris Ripps [1 ]
Haohua Qian [2 ]
Jane Zakevicius [1 ]
机构
[1] University of Illinois College of Medicine,Department of Ophthalmology and Visual Sciences
[2] University of Illinois College of Medicine,Department of Anatomy and Cell Biology
[3] University of Illinois College of Medicine,Department of Biological Sciences
关键词
connexin26; hemichannels; connexons; membrane currents; gap junctions; retinal horizontal cells; carbenoxolone; NPPB; pH; calcium; quinine;
D O I
10.1023/B:CEMN.0000036403.43484.3d
中图分类号
学科分类号
摘要
1. Hemichannels formed by connexin26 (Cx26) on the horizontal cell dendrites that invaginate cone terminals in the vertebrate retina have been implicated in the feedback mechanism by which horizontal cells regulate transmitter release from cone photoreceptors. However, their membrane properties had not been studied previously, and it was unclear whether they could subserve their purported function at the membrane potentials over which horizontal cells operate.
引用
收藏
页码:647 / 665
页数:18
相关论文
共 50 条
  • [1] Differing properties of human and mouse connexin26 hemichannels and gap junctional channels expressed in Xenopus oocytes
    Hoang, QV
    Udawatte, C
    Qian, H
    Kumar, NM
    Ripps, H
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46
  • [2] Properties of connexin50 hemichannels expressed in Xenopus laevis oocytes
    Eskandari, S
    Zampighi, GA
    GAP JUNCTIONS: MOLECULAR BASIS OF CELL COMMUNICATION IN HEALTH AND DISEASE, 2000, 49 : 369 - 388
  • [3] Histidine suppresses zinc modulation of connexin hemichannels expressed in Xenopus oocytes
    不详
    BIOLOGICAL BULLETIN, 2004, 207 (02): : 158 - 159
  • [4] Rational design of new NO and redox sensitivity into connexin26 hemichannels
    Meigh, Louise
    Cook, Daniel
    Zhang, Jie
    Dale, Nicholas
    OPEN BIOLOGY, 2015, 5 (02)
  • [5] Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes
    Bruzzone, R
    Barbe, MT
    Jakob, NJ
    Monyer, H
    JOURNAL OF NEUROCHEMISTRY, 2005, 92 (05) : 1033 - 1043
  • [6] Evolutionary adaptation of the sensitivity of connexin26 hemichannels to CO2
    de Wolf, Elizabeth
    Cook, Jonathan
    Dale, Nicholas
    PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2017, 284 (1848)
  • [7] Insights on small molecular permeation and gating functions of Connexin26 hemichannels
    Zhang, Han
    Botello-Smith, Wesley
    Chatterjee, Payal
    Chang, Paul
    Luo, Yun
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [8] Divalent regulation and intersubunit interactions of human Connexin26 (Cx26) hemichannels
    Lopez, William
    Liu, Yu
    Harris, Andrew L.
    Contreras, Jorge E.
    CHANNELS, 2014, 8 (01) : 1 - 4
  • [9] Aminosulfonate modulated pH-induced conformational changes in connexin26 hemichannels
    Yu, Jinshu
    Bippes, Christian A.
    Hand, Galen M.
    Muller, Daniel J.
    Sosinsky, Gina E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (12) : 8895 - 8904
  • [10] CONNEXIN46 FORMS GAP JUNCTIONAL HEMICHANNELS IN XENOPUS OOCYTES
    EBIHARA, L
    STEINER, E
    FASEB JOURNAL, 1992, 6 (01): : A408 - A408