RETRACTED: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications (Retracted article. See vol. 15, 2025)

被引：33

作者：

Eivazzadeh-Keihan, Reza ^{[1
]}

Alimirzaloo, Farkhondeh ^{[1
]}

Aliabadi, Hooman Aghamirza Moghim ^{[2
,3
]}

Noruzi, Ehsan Bahojb ^{[4
]}

Akbarzadeh, Ali Reza ^{[5
]}

Maleki, Ali ^{[1
]}

Madanchi, Hamid ^{[6
,7
]}

Mahdavi, Mohammad ^{[8
]}

机构：

[1] Iran Univ Sci & Technol, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran

[2] Pasteur Inst Iran, Biotechnol Res Ctr, Dept Med Biotechnol, Prot Chem Lab, Tehran, Iran

[3] KN Toosi Univ Technol, Dept Chem, Adv Chem Studies Lab, Tehran, Iran

[4] Univ Tabriz, Fac Chem, Dept Inorgan Chem, Tabriz, Iran

[5] Iran Univ Sci & Technol, Dept Chem, Tehran 1684613114, Iran

[6] Semnan Univ Med Sci, Sch Med, Dept Biotechnol, Semnan, Iran

[7] Pasteur Inst Iran, Biotechnol Res Ctr, Dept Med Biotechnol, Drug Design & Bioinformat Unit, Tehran, Iran

[8] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

MECHANICAL-PROPERTIES; AQUEOUS DISPERSIONS; GRAPHITE OXIDE; HYDROGEL; NANOMATERIALS; REDUCTION; SCAFFOLD; NANOCOMPOSITES; DEGRADATION; BIOSENSORS;

D O I：

10.1038/s41598-022-10212-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In this paper, a novel graphene oxide-folic acid/silk fibroin (GO-FA/SF) nanobiocomposite scaffold was designed and fabricated using affordable and non-toxic materials. The GO was synthesized using the hummer method, covalently functionalized with FA, and then easily conjugated with extracted SF via the freeze-drying process. For characterization of the scaffold, several techniques were employed: Fourier-transform infrared (FT-IR), field emission scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), and thermogravimetric analysis (TGA). The cell viability method, hemolysis, and anti-biofilm assays were performed, exploring the biological capability of the nanobiocomposite. The cell viability percentages were 96.67, 96.35 and 97.23% for 24, 48, and 72 h, respectively, and its hemolytic effect was less than 10%. In addition, it was shown that this nanobiocomposite prevents the formation of Pseudomonas aeruginosa biofilm and has antibacterial activity.

引用

页数：12

共 76 条

[1] Effect of functional groups on the thermal degradation of phosphorus- and phosphorus/nitrogen-containing functional polymers [J].