Development and Validation of UV Spectrophotometric Method for Determination of Paracetamol in Chitosan Coated Alginate Beads and Dissolution Studies

This study was aimed at developing and validating a UV spectrophotometric method for the estimation of paracetamol in chitosan coated alginate beads throughout their pharmaceutical development. Paracetamol content was assessed at 234 nm in various buffers to cover the physiological range of gastrointestinal fluid from pH 1.2 to pH 6.8. The linearity range was found to be 0.5–10 μg/mL. The proposed UV method was validated in accordance with main ICH guidelines. The findings showed that this UV spectrophotometric method is accurate, precise, and reproducible while also being uncomplicated, cost-effective, and not requiring a lot of time. It can be used to estimate paracetamol in routine quality control and drug dissolution studies.