Development and Validation of UV Spectrophotometric Method for Determination of Paracetamol in Chitosan Coated Alginate Beads and Dissolution Studies

被引：0
作者：
Samah Hamed Almurisi
Abd Almonem Doolaanea
Khater Ahmed Al-Japairai
Bappaditya Chatterjee
Md Zaidul Islam Sarker
机构：
[1] International Islamic University Malaysia,Department of Pharmaceutical Technology, Kulliyyah of Pharmacy
[2] International Islamic University Malaysia,IKOP Sdn Bhd, Kulliyyah of Pharmacy
[3] University Malaysia Pahang,Department of Pharmaceutical Engineering, Faculty of Chemical and Process Engineering Technology
[4] Department of Pharmaceutics,undefined
[5] SPPSPTM,undefined
[6] SVKM’s NMIMS (Deemed to be University),undefined
来源：
Pharmaceutical Chemistry Journal | 2022年 / 56卷
关键词：
paracetamol; UV spectrophotometric method; validation; dissolution;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This study was aimed at developing and validating a UV spectrophotometric method for the estimation of paracetamol in chitosan coated alginate beads throughout their pharmaceutical development. Paracetamol content was assessed at 234 nm in various buffers to cover the physiological range of gastrointestinal fluid from pH 1.2 to pH 6.8. The linearity range was found to be 0.5–10 μg/mL. The proposed UV method was validated in accordance with main ICH guidelines. The findings showed that this UV spectrophotometric method is accurate, precise, and reproducible while also being uncomplicated, cost-effective, and not requiring a lot of time. It can be used to estimate paracetamol in routine quality control and drug dissolution studies.
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页码：1011 / 1016
页数：5
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