Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations

被引:0
作者
Tomoka Furukawa
Kanako Wakabayashi
Ai Tamura
Hiroshi Nakagawa
Yoshihiro Morishima
Yoichi Osawa
Toshihisa Ishikawa
机构
[1] Tokyo Institute of Technology,Department of Biomolecular Engineering, Graduate School of Bioscience and Biotechnology
[2] Japanese Society for the Promotion of Science (JSPS),Department of Pharmacology
[3] The University of Michigan Medical School,undefined
来源
Pharmaceutical Research | 2009年 / 26卷
关键词
ABCG2; endoplasmic reticulum associated degradation (ERAD); proteasome; SNP; ubiquitin;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:469 / 479
页数:10
相关论文
共 21 条
  • [1] Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations
    Furukawa, Tomoka
    Wakabayashi, Kanako
    Tamura, Ai
    Nakagawa, Hiroshi
    Morishima, Yoshihiro
    Osawa, Yoichi
    Ishikawa, Toshihisa
    PHARMACEUTICAL RESEARCH, 2009, 26 (02) : 469 - 479
  • [2] Contrasting roles of the ABCG2 Q141K variant in prostate cancer
    Sobek, Kathryn M.
    Cummings, Jessica L.
    Bacich, Dean J.
    O'Keefe, Denise S.
    EXPERIMENTAL CELL RESEARCH, 2017, 354 (01) : 40 - 47
  • [3] BCRP/ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity
    Wen, Xia
    Kozlosky, Danielle
    Zhang, Ranran
    Doherty, Cathleen
    Buckley, Brian
    Barrett, Emily
    Aleksunes, Lauren M.
    DRUG METABOLISM AND DISPOSITION, 2021, 49 (08) : 629 - 637
  • [4] Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2
    Nakagawa, Hiroshi
    Tamura, Ai
    Wakabayashi, Kanako
    Hoshijima, Kazuyuki
    Komada, Masayuki
    Yoshida, Takashi
    Kometani, Satoshi
    Matsubara, Takayoshi
    Mikuriya, Kenta
    Ishikawa, Toshihisa
    BIOCHEMICAL JOURNAL, 2008, 411 : 623 - 631
  • [5] Joint Effects of Alcohol Consumption and ABCG2 Q141K on Chronic Tophaceous Gout Risk
    Tu, Hung-Pin
    Ko, Albert Min-Shan
    Chiang, Shang-Lun
    Lee, Su-Shin
    Lai, Han-Ming
    Chung, Chia-Min
    Huang, Chung-Ming
    Lee, Chien-Hung
    Kuo, Tzer-Min
    Hsieh, Mei-Jung
    Ko, Ying-Chin
    JOURNAL OF RHEUMATOLOGY, 2014, 41 (04) : 749 - 758
  • [6] Impact of Q141K on the Transport of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors by ABCG2
    Inoue, Yutaka
    Morita, Takashi
    Onozuka, Mari
    Saito, Ken-ichi
    Sano, Kazumi
    Hanada, Kazuhiko
    Kondo, Masami
    Nakamura, Yoichi
    Kishino, Tohru
    Nakagawa, Hiroshi
    Ikegami, Yoji
    CELLS, 2019, 8 (07)
  • [7] Value of ABCG2 Q141K and Q126X genotyping in predicting risk of preeclampsia in Chinese Han women population
    Hou, Huabin
    Geng, Meiyun
    Zhang, Ru
    Liu, Wenmiao
    Wang, Jingli
    Li, Jing
    Lin, Yan
    Liu, Shiguo
    Wang, Zhongjun
    Guo, Hui
    Guan, Hongzai
    Tan, Ping
    PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH, 2019, 17 : 197 - 202
  • [8] The 315–316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant
    Orsolya Polgar
    John F. Deeken
    Lilangi S. Ediriwickrema
    Akina Tamaki
    Seth M. Steinberg
    Robert W. Robey
    Susan E. Bates
    Molecular and Cellular Biochemistry, 2009, 322 : 63 - 71
  • [9] The ABCG2 gene Q141K polymorphism contributes to an increased risk of gout: A meta-analysis of 2185 cases
    Qiu, Ya
    Liu, Hua
    Qing, Yufeng
    Yang, Min
    Tan, Xiaoyao
    Zhao, Mingcai
    Lin, Monica
    Zhou, Jingguo
    MODERN RHEUMATOLOGY, 2014, 24 (05) : 829 - 834
  • [10] The 315-316 deletion determines the BXP-21 antibody epitope but has no effect on the function of wild type ABCG2 or the Q141K variant
    Polgar, Orsolya
    Deeken, John F.
    Ediriwickrema, Lilangi S.
    Tamaki, Akina
    Steinberg, Seth M.
    Robey, Robert W.
    Bates, Susan E.
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2009, 322 (1-2) : 63 - 71