Soy protein, isoflavonoids, and risk of developing coronary heart disease

被引：6

作者：

Lichtenstein A.H. ^{[1
]}

机构：

[1] Jean Mayer USDA Human Nutrition Research, Center on Aging at Tufts University, 711 Washington Street, Boston

来源：

Current Atherosclerosis Reports | 1999年 / 1卷 / 3期

关键词：

Arterioscler Thromb Vasc Biol; Daidzein; Equol; Genistein; Isoflavones;

D O I：

10.1007/s11883-999-0034-6

中图分类号：

学科分类号：

摘要：

The effects of soy protein and isoflavones on blood cholesterol in humans has been variable. Maximal low-density lipoprotein cholesterol lowering appears to be modest and consistently ranges from 5% to 7%. Preliminary evidence suggests a potentially beneficial effect of the isoflavone fraction of soybeans on arterial compliance. The isoflavone fraction has been demonstrated to decrease the in vitro susceptibility of low-density lipoprotein to oxidation; the significance of this finding in vivo is unknown. It is difficult to definitively say at this time whether increased consumption of soy based products will result in a decreased risk of CHD beyond their ability to displace foods high in saturated fat and cholesterol from the diet. © 1999, Current Science Inc.

引用

页码：210 / 214

共 38 条

[1]

Carroll, K.K., Kurowska, E.M., Soy consumption and cholesterol reduction: review of animal and human studies (1995) J Nutr, 125, pp. 594S-597S. , PID: 7884539, COI: 1:CAS:528:DyaK2MXktFGmurg%3D

[2]

Lichtenstein, A.H., Soy protein, isoflavones and cardiovascular disease risk (1998) J Nutr, 128, pp. 1589-1592. , PID: 9772121, COI: 1:CAS:528:DyaK1cXmtlGqtLo%3D

[3]

Hodges, R.E., Krehl, W.A., Stone, D.B., Lopez, A., Dietary carbohydrates and low cholesterol diets: effects on serum lipids of man (1967) Am J Clin Nutr, 20, pp. 198-208. , PID: 6020521, COI: 1:CAS:528:DyaF2sXmtlWjsg%3D%3D

[4]

Sirtori, C.R., Lovati, M.R., Manzoni, C., Soy and cholesterol reduction: clinical experience (1995) J Nutr, 125, pp. 598S-605S. , PID: 7884540, COI: 1:CAS:528:DyaK2MXktFGmurk%3D

[5]

Anderson, J.W., Johnstone, B.M., Cook-Newell, M.E., Meta-analysis of the effects of soy protein intake on serum lipids (1995) N Engl J Med, 333, pp. 276-282. , PID: 7596371, COI: 1:CAS:528:DyaK2MXntlKht74%3D

[6]

Nilausen, K., Meinertz, H., Variable lipemic response to dietary soy protein in healthy, normolipemic men (1998) Am J Clin Nutr, 68, pp. 1380S-1384S. , PID: 9848503, COI: 1:CAS:528:DyaK1cXnvV2gtLs%3D

[7]

Nilausen, K., Meinertz, H., Lipoprotein (a) and dietary proteins: casein lowers lipoprotein (a) concentrations as compared with soy protein (1999) Am J Clin Nutr, 69, pp. 419-425. , PID: 10075325, COI: 1:CAS:528:DyaK1MXhslWnsL0%3D

[8]

Wild, S.H., Fortmann, S.P., Marcovina, S.M., A prospective case-control study of lipoprotein (a) levels and apo(a) size and risk of coronary heart disease in Stanford Five-City Project participants (1997) Arterioscler Thromb, 17, pp. 239-245. , COI: 1:STN:280:DyaK2s3gsFCrtw%3D%3D

[9]

Brown, S.A., Morrisett, J.D., Boerwinkle, E., The relation of lipoprotein[a] concentrations and apolipoprotein[a] phenotypes with asymptomatic atherosclerosis in subjects of the Atherosclerosis Risk in Communities (ARIC) study (1993) Arterioscler Thromb, 13, pp. 1558-1566. , PID: 8218095, COI: 1:CAS:528:DyaK2cXhvVyls74%3D

[10]

Wong, W.W., Smith, E.O., Stuff, J.E., Cholesterol-lowering effect of soy protein in normocholesterolemic and hypercholesterolemic men (1998) Am J Clin Nutr, 68, pp. 1385S-1389S. , PID: 9848504, COI: 1:CAS:528:DyaK1cXnvV2gtbs%3D

← 1 2 3 4 →