Cerebrospinal fluid from Alzheimer’s disease patients promotes tau aggregation in transgenic mice

被引:0
作者
Zhiva Skachokova
Alfonso Martinisi
Martin Flach
Frederik Sprenger
Yvonne Naegelin
Viviane Steiner-Monard
Marc Sollberger
Andreas U. Monsch
Michel Goedert
Markus Tolnay
David T. Winkler
机构
[1] University Hospital Basel,Institute of Medical Genetics and Pathology
[2] University Hospital Basel,Department of Neurology
[3] Felix Platter Hospital & University of Basel,Memory Clinic, University Center for Medicine of Aging
[4] Laboratory of Molecular Biology,MRC
[5] Medical University Clinic,Neurology
来源
Acta Neuropathologica Communications | / 7卷
关键词
Alzheimer’s disease; Neurodegeneration; Tau; Cerebrospinal fluid; Seeding; Prion; Transgenic mouse models;
D O I
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中图分类号
学科分类号
摘要
Tau is a microtubule stabilizing protein that forms aggregates in Alzheimer’s disease (AD). Tau derived from AD patients’ brains induces tau aggregation in a prion-like manner when injected into susceptible mouse models.
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