Ocular bacterial infections and antibiotic resistance patterns in patients attending Gondar Teaching Hospital, Northwest Ethiopia

被引：25

作者：

Belyhun Y. ^{[1
]}

Moges F. ^{[1
]}

Endris M. ^{[1
]}

Asmare B. ^{[2
]}

Amare B. ^{[3
]}

Bekele D. ^{[4
]}

Tesfaye S. ^{[5
]}

Alemayehu M. ^{[1
]}

Biadgelegne F. ^{[6
]}

Mulu A. ^{[1
]}

Assefa Y. ^{[7
]}

机构：

[1] School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar

[2] Arada Sub-city Health Office CDC Project, Addis Ababa City Health Bureau, Addis Ababa

[3] Department of Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar

[4] Natural and Computational Sciences, Department of Biology, Debre Markos University, Debre Markos

[5] Natural and Computational Sciences, Department of Biology, University of Gondar, Gondar

[6] Faculty of Medicine and Health Sciences, Bahir Dar University, Bahir Dar

[7] Department of Ophthalmology, College of Medicine and Health Sciences, University of Gondar, Gondar

来源：

BMC Research Notes | / 11卷 / 1期

关键词：

Antibiotic resistance; Ethiopia; Ocular infections;

D O I：

10.1186/s13104-018-3705-y

中图分类号：

学科分类号：

摘要：

Objectives: Empirical selections of antimicrobial therapy based on clinical observations are common clinical practices in Ethiopia. This study identified common external ocular infections and determined antibiotic susceptibility testing in northwest Ethiopia. Results: Among 210 patients studied, conjunctivitis 32.9%(69), blepharitis 26.7%(56), dacryocystitis 14.8%(51), blepharoconjunctivitis 11.9%(25), and trauma 10.0%(21) were the most common external ocular infections. Pathogenic bacteria were isolated among 62.4%(131) cases. The distributions of bacteria detected in conjunctivitis, dacryocystitis, and blepharitis patients were 32.8%(43), 23.7%(31), and 16.0%(21), respectively. The most prevalent isolates were coagulase negative Staphylococci; 27.5%(36), S. aureus; 26.7%(35), Pseudomonas species; 10.7%(14), and E. coli; 7.6%(10). Tetracycline, amoxicillin, chloramphenicol, ampicillin, and nalidic acid showed resistance to bacterial isolates with a respective prevalence of 35.9%(47), 32.1%(42), 26.2%(34), 25.2%(33), and 23.7%(31). Multi-drug resistance patterns to the commonly prescribed antibiotics tested was 20.6%(27), 18.3%(24), 17.6%(23), 5.3%(7), and 4.6%(6) to two, three, four, five, and six antibiotics, respectively. Overall, the multi-drug resistance prevalence rate was 66.4%(87). This study confirmed diverse types of external ocular manifestations associated with bacterial infections with wide ranges of antibiotic resistant phenotypes. Thus, combining clinical information, bacteriological analysis, and antimicrobial susceptibility tests are useful for making an evidence-based selection of antibiotics therapy. © 2018 The Author(s).

引用

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