PD-1 blockade induces responses by inhibiting adaptive immune resistance

被引：0
|
作者：
Paul C. Tumeh
Christina L. Harview
Jennifer H. Yearley
I. Peter Shintaku
Emma J. M. Taylor
Lidia Robert
Bartosz Chmielowski
Marko Spasic
Gina Henry
Voicu Ciobanu
Alisha N. West
Manuel Carmona
Christine Kivork
Elizabeth Seja
Grace Cherry
Antonio J. Gutierrez
Tristan R. Grogan
Christine Mateus
Gorana Tomasic
John A. Glaspy
Ryan O. Emerson
Harlan Robins
Robert H. Pierce
David A. Elashoff
Caroline Robert
Antoni Ribas
机构：
[1] University of California Los Angeles (UCLA),
[2] Jonsson Comprehensive Cancer Center,undefined
[3] Merck & Co,undefined
[4] Gustave Roussy and INSERM U981,undefined
[5] Villejuif,undefined
[6] Paris Sud,undefined
[7] France,undefined
[8] Adaptive Biotechnologies,undefined
[9] Fred Hutchinson Cancer Research Center,undefined
来源：
Nature | 2014年 / 515卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The dynamics of T-cell responses are investigated in tumour tissue from patients with advanced melanoma who were treated with a PD-1-blocking monoclonal antibody, revealing that clinical efficacy of the treatment correlates with increased frequencies of pre-existing CD8+ T cells and PD-1 and PD-L1 expression.
引用
收藏
页码：568 / 571
页数：3
相关论文
共 50 条
  • [1] PD-1 blockade induces responses by inhibiting adaptive immune resistance
    Tumeh, Paul C.
    Harview, Christina L.
    Yearley, Jennifer H.
    Shintaku, I. Peter
    Taylor, Emma J. M.
    Robert, Lidia
    Chmielowski, Bartosz
    Spasic, Marko
    Henry, Gina
    Ciobanu, Voicu
    West, Alisha N.
    Carmona, Manuel
    Kivork, Christine
    Seja, Elizabeth
    Cherry, Grace
    Gutierrez, Antonio J.
    Grogan, Tristan R.
    Mateus, Christine
    Tomasic, Gorana
    Glaspy, John A.
    Emerson, Ryan O.
    Robins, Harlan
    Pierce, Robert H.
    Elashoff, David A.
    Robert, Caroline
    Ribas, Antoni
    NATURE, 2014, 515 (7528) : 568 - +
  • [2] PD-1 blockade unblocks immune responses to vaccination
    Kedzierska, Katherine
    Nguyen, Thi H. O.
    NATURE IMMUNOLOGY, 2022, 23 (08) : 1135 - 1137
  • [3] PD-1 blockade unblocks immune responses to vaccination
    Katherine Kedzierska
    Thi H. O. Nguyen
    Nature Immunology, 2022, 23 : 1135 - 1137
  • [4] Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
    Koyama, Shohei
    Akbay, Esra A.
    Li, Yvonne Y.
    Herter-Sprie, Grit S.
    Buczkowski, Kevin A.
    Richards, William G.
    Gandhi, Leena
    Redig, Amanda J.
    Rodig, Scott J.
    Asahina, Hajime
    Jones, Robert E.
    Kulkarni, Meghana M.
    Kuraguchi, Mari
    Palakurthi, Sangeetha
    Fecci, Peter E.
    Johnson, Bruce E.
    Janne, Pasi A.
    Engelman, Jeffrey A.
    Gangadharan, Sidharta P.
    Costa, Daniel B.
    Freeman, Gordon J.
    Bueno, Raphael
    Hodi, F. Stephen
    Dranoff, Glenn
    Wong, Kwok-Kin
    Hammerman, Peter S.
    NATURE COMMUNICATIONS, 2016, 7
  • [5] Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints
    Shohei Koyama
    Esra A. Akbay
    Yvonne Y. Li
    Grit S. Herter-Sprie
    Kevin A. Buczkowski
    William G. Richards
    Leena Gandhi
    Amanda J. Redig
    Scott J. Rodig
    Hajime Asahina
    Robert E. Jones
    Meghana M. Kulkarni
    Mari Kuraguchi
    Sangeetha Palakurthi
    Peter E. Fecci
    Bruce E. Johnson
    Pasi A. Janne
    Jeffrey A. Engelman
    Sidharta P. Gangadharan
    Daniel B. Costa
    Gordon J. Freeman
    Raphael Bueno
    F. Stephen Hodi
    Glenn Dranoff
    Kwok-Kin Wong
    Peter S. Hammerman
    Nature Communications, 7
  • [6] PD-1 Blockade Boosts Radiofrequency Ablation-Elicited Adaptive Immune Responses against Tumor
    Shi, Liangrong
    Chen, Lujun
    Wu, Changping
    Zhu, Yibei
    Xu, Bin
    Zheng, Xiao
    Sun, Mingfen
    Wen, Wen
    Dai, Xichao
    Yang, Min
    Lv, Quansheng
    Lu, Binfeng
    Jiang, Jingting
    CLINICAL CANCER RESEARCH, 2016, 22 (05) : 1173 - 1184
  • [7] PD-1 blockade boosts radiofrequency ablation-elicited adaptive immune responses against tumor
    Jiang, J.
    Shi, L.
    Chen, L.
    Zhu, Y.
    Wu, C.
    Lu, B.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 206 - 207
  • [8] Toward better selection of PD-1 blockade responders through direct markers of adaptive immune resistance
    Shin, Daniel S.
    Garcia-Diaz, Angel
    Escuin-Ordinas, Helena
    Palaskas, Nicolaos J.
    Komenan, Sara M.
    Graeber, Thomas G.
    Comin-Anduix, Begonya
    Ribas, Antoni
    CANCER RESEARCH, 2015, 75
  • [9] Resistance to PD-1 blockade in melanoma
    Burki, Talha Khan
    LANCET ONCOLOGY, 2016, 17 (09): : E376 - E376
  • [10] DGKA Mediates Resistance to PD-1 Blockade
    Fu, Lingyi
    Li, Sen
    Xiao, WeiWei
    Yu, Kuai
    Li, Shuo
    Yuan, Sujing
    Shen, Jianfei
    Dong, Xingjun
    Fang, Ziqian
    Zhang, Jianeng
    Chen, Siyu
    Li, Wende
    You, Hua
    Xia, Xiaojun
    Kang, Tiebang
    Tan, Jing
    Chen, Gong
    Yang, An-Kui
    Gao, YuanHong
    Zhou, Penghui
    CANCER IMMUNOLOGY RESEARCH, 2021, 9 (04) : 371 - 385
12345