Endothelin-1 levels and biomarkers of oxidative stress in glaucoma patients

被引：0
作者：
N. López-Riquelme
C. Villalba
C. Tormo
A. Belmonte
C. Fernandez
G. Torralba
F. Hernández
机构：
[1] General University Hospital,Clinical Laboratory
[2] General University Hospital,Ophthalmology Department
[3] University Hospital of Elche Camino de La Almazara,Department of Biochemistry
来源：
International Ophthalmology | 2015年 / 35卷
关键词：
Oxidative stress; Vitamins; Endothelin; Homocysteine; Glaucoma;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
To investigate the levels of endothelin-1 (ET-1), homocysteine (Hcy), vitamins A, E, B12 and folic acid in plasma of patients with different types of glaucoma: primary open-angle glaucoma (POAG) and normotensive glaucoma (NTG). Patients were classified into 3 groups: group POAG comprised 48 patients, group NTG comprised 15 patients, and control group that comprised 75 healthy subjects. ET-1 levels were measured by ELISA, Vitamins A and E by HPLC, and Vitamin B12, homocysteine, and folic acid levels were determined by chemiluminescent immunoassay. The ET-1 and Hcy levels were significantly higher (p = 0.002) in the POAG group compared to NTG and control group. Vitamin E levels were significantly lower (p = 0.001) in the NTG group compared to POAG and control group. The increase of Hcy and ET-1 in POAG patients is related to vascular endothelial dysfunction. Thus results may play a key role in the development of this disease. Lower levels of Vitamin E in the NTG group suggest that oxidative process plays an early role in the development of this type of glaucoma.
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页码：527 / 532
页数：5
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