The synthesis of 2H-pyrido[3,4-c][1,2]benzoxazine-2,4(3H)-diones from 6-oxo-6H-1,2-oxazine-3-carboxylates

被引：0
|
作者：
Dmitry S. Ivanov
Elvira R. Zaitseva
Alexander Yu. Smirnov
Alexey V. Nizovtsev
Nadezhda S. Baleeva
Mikhail S. Baranov
机构：
[1] Russian Academy of Sciences,Shemyakin
[2] Pirogov Russian National Research Medical University,Ovchinnikov Institute of Bioorganic Chemistry
来源：
Chemistry of Heterocyclic Compounds | 2023年 / 59卷
关键词：
imides; nitroacetic esters; oxazinones; condensation;
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摘要：
A simple procedure was developed for the synthesis of 2H-pyrido[3,4-c][1,2]benzoxazine-2,4(3H)-diones by the treatment of o-fluorophenyl-substituted 6-oxo-6H-1,2-oxazine-3-carboxylates with primary amines. The reaction proceeded according to the mechanism previously described for the formation of 3-(hydroxyimino)pyridine-2,6-diones followed by intramolecular nucleophilic substitution involving the hydroxyimino group to form the 1,2-oxazine ring.
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页码：101 / 104
页数：3
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